CAS Number81110-73-8
SynonymsAcetorphan; Tiorfan; Hidrasec; Tiorfix; Redotil; MFCD00865520; Benzyl N-[3-(acetylsulfanyl)-2-benzylpropanoyl]glycinate; Racecadotril; RACECADOTRIL: ACETORPHAN; RACECADORTRIL; Glycine, N-[3-(acetylthio)-1-oxo-2-(phenylmethyl)propyl]-, phenylmethyl ester
Molecular FormulaC21H23NO4S
Molecular Weight385.48
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point574.5±50.0 °C at 760 mmHg
Melting Point89ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 81110-73-8 |
| Catalog No. | 2A-9012252 |
| Chinese Name | 消旋卡多曲 |
| Synonyms | Acetorphan; Tiorfan; Hidrasec; Tiorfix; Redotil; MFCD00865520; Benzyl N-[3-(acetylsulfanyl)-2-benzylpropanoyl]glycinate; Racecadotril; RACECADOTRIL: ACETORPHAN; RACECADORTRIL; Glycine, N-[3-(acetylthio)-1-oxo-2-(phenylmethyl)propyl]-, phenylmethyl ester |
| Molecular Formula | C21H23NO4S |
| Molecular Weight | 385.48 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 574.5±50.0 °C at 760 mmHg |
| Melting Point | 89ºC |
| Appearance | powder |
| Storage Condition | Refrigerator |
| Application | Racecadotril (acetorphan) is an enkephalinase inhibitor with an IC50 of 4.5 uM and can inhibit the degradation of endogenous enkephalin. |
| HTC | 2930909090 |
| PubChem ID | 329825113 |
| MDL Number | MFCD00865520 |
| SMILES | CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc2ccccc2 |
| InChI | 1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25) |
| InChI Key | ODUOJXZPIYUATO-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/12252_1_81110_73_8.pdf |
| Bioactivity | Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin Research Areas >> Neurological Disease References [1]. Marion Eberlin, Tobias Mück, Martin C. Michel, et al. A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril. Front Pharmacol. 2012; 3: 93. [2]. Wu HT, Chang CK, Cheng KC, et al. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Horm Metab Res. 2010 Apr;42(4):261-7. [3]. Szajewska H, Ruszczyński M, Chmielewska A, Wieczorek J. Systematic review: racecadotril in the treatment of acute diarrhoea in children. Aliment Pharmacol Ther. 2007 Sep 15;26(6):807-13. [4]. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000 Feb;14(1):75-9. [5]. Racecadotril Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 574.5±50.0 °C at 760 mmHg Melting Point 89ºC Molecular Formula C21H23NO4S Molecular Weight 385.477 Flash Point 301.2±30.1 °C Exact Mass 385.134766 PSA 97.77000 LogP 3.44 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.579 InChIKey ODUOJXZPIYUATO-UHFFFAOYSA-N SMILES CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc1ccccc1 Storage condition Refrigerator |
| Use of | Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy. Properties Articles27 Name Racecadotril Synonym More Synonyms Racecadotril Biological Activity Description Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin Research Areas >> Neurological Disease References [1]. Marion Eberlin, Tobias Mück, Martin C. Michel, et al. A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril. Front Pharmacol. 2012; 3: 93. [2]. Wu HT, Chang CK, Cheng KC, et al. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Horm Metab Res. 2010 Apr;42(4):261-7. [3]. Szajewska H, Ruszczyński M, Chmielewska A, Wieczorek J. Systematic review: racecadotril in the treatment of acute diarrhoea in children. Aliment Pharmacol Ther. 2007 Sep 15;26(6):807-13. [4]. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000 Feb;14(1):75-9. [5]. Racecadotril Chemical & Physical Properties Molecular Formula C21H23NO4S Exact Mass 385.134766 PSA 97.77000 Index of Refraction 1.579 InChIKey ODUOJXZPIYUATO-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((+-)-N-(2- ((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((+-)-N-(2- ((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. ((+-)-N-(2-((Acetylthio)methyl)-1-oxo-3- phenylpropyl)glycine phenylmethyl ester) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), See reverse side of invoice or packing slip. |
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