CAS Number88678-67-5
SynonymsCarbamothioic acid, N-(6-methoxy-2-pyridinyl)-N-methyl-, O-[3-(1,1-dimethylethyl)phenyl] ester; O-(3-tert-Butylphenyl) (6-methoxypyridin-2-yl)methylcarbamothioate; (6-Méthoxy-2-pyridinyl)méthylthiocarbamate de O-[3-(2-méthyl-2-propanyl)phényle]; O-(3-tert-Butylphenyl)-(6-methoxypyridin-2-yl)methylthiocarbamat; TSH-888; O-[3-(1,1-Dimethylethyl)phenyl] (6-methoxy-2-pyridinyl)methylcarbamothioate; Pyributicarb [ISO]; O-[3-(1,1-dimethylethyl)phenyl] N-(6-methoxy-2-pyridinyl)-N-methylcarbamothioate; Carbamothioic acid,(6-methoxy-2-pyridinyl)methyl-,O-(3-(1,1-dimethylethyl)phenyl) ester; O-(3-tert-butylphenyl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate; O-[3-(2-Methyl-2-propanyl)phenyl]-(6-methoxy-2-pyridinyl)methylthiocarbamat; O-[3-(2-Methyl-2-propanyl)phenyl] (6-methoxy-2-pyridinyl)meth
Molecular FormulaC18H22N2O2S
Molecular Weight330.45
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point427.8±55.0 °C at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 88678-67-5 |
| Catalog No. | 2A-9012206 |
| Chinese Name | 稗草畏 |
| Synonyms | Carbamothioic acid, N-(6-methoxy-2-pyridinyl)-N-methyl-, O-[3-(1,1-dimethylethyl)phenyl] ester; O-(3-tert-Butylphenyl) (6-methoxypyridin-2-yl)methylcarbamothioate; (6-Méthoxy-2-pyridinyl)méthylthiocarbamate de O-[3-(2-méthyl-2-propanyl)phényle]; O-(3-tert-Butylphenyl)-(6-methoxypyridin-2-yl)methylthiocarbamat; TSH-888; O-[3-(1,1-Dimethylethyl)phenyl] (6-methoxy-2-pyridinyl)methylcarbamothioate; Pyributicarb [ISO]; O-[3-(1,1-dimethylethyl)phenyl] N-(6-methoxy-2-pyridinyl)-N-methylcarbamothioate; Carbamothioic acid,(6-methoxy-2-pyridinyl)methyl-,O-(3-(1,1-dimethylethyl)phenyl) ester; O-(3-tert-butylphenyl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate; O-[3-(2-Methyl-2-propanyl)phenyl]-(6-methoxy-2-pyridinyl)methylthiocarbamat; O-[3-(2-Methyl-2-propanyl)phenyl] (6-methoxy-2-pyridinyl)meth |
| Molecular Formula | C18H22N2O2S |
| Molecular Weight | 330.45 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 427.8±55.0 °C at 760 mmHg |
| Storage Condition | Refrigerated at 0-6°C |
| Application | Pyributicarb is a carbamate herbicide and a potent activator of the CYP3A4 gene and the human pregnane X receptor (hPXR). |
| HTC | 2933399029 |
| MDL Number | C18H22N2O2S |
| SMILES | COc1cccc(N(C)C(=S)Oc2cccc(C(C)(C)C)c2)n1 |
| InChI | InChI=1S/C18H22N2O2S/c1-18(2,3)13-8-6-9-14(12-13)22-17(23)20(4)15-10-7-11-16(19-15)21-5/h6-12H,1-5H3 |
| InChI Key | VTRWMTJQBQJKQH-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/12206_1_88678_67_5.pdf |
| Bioactivity | Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology Target CYP3A4[1], hPXR[2] In Vitro Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells[1]. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF)[2]. In Vivo Pyributicarb causes enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus[1]. Cell Assay HepG2-derived cells stably expressing the CYP3A4 reporter gene (3-1-10 cells) are used in this experiment. The cells are treated with 0.3 to 30 μM Pyributicarb for 48 h. Then reporter activities are determined[1]. Animal Admin Male ICR mice (5 weeks old) are used and fed standard rodent chow. After 18-h fasting, mice are injected i.v. with adenovirus [4.0 ×109 50% titer culture infectious dose (TCID50)/mouse]. Three days after the infection, vehicle (0.5% methyl cellulose/saline) or Pyributicarb (100 mg/kg/day) is administered p.o. for 2 consecutive days. Animals are killed 20 h after the last dose[1]. References [1]. Matsubara T, et al. Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab Dispos. 2007 May;35(5):728-33. [2]. Kojima H, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280(3):77-87. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 427.8±55.0 °C at 760 mmHg Molecular Formula C18H22N2O2S Molecular Weight 330.444 Flash Point 212.5±31.5 °C Exact Mass 330.140198 PSA 75.47000 LogP 5.21 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.599 InChIKey VTRWMTJQBQJKQH-UHFFFAOYSA-N SMILES COc1cccc(N(C)C(=S)Oc2cccc(C(C)(C)C)c2)n1 Storage condition 0-6°C |
| Use of | Properties Name pyributicarb Synonym More Synonyms Pyributicarb Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology CYP3A4[1], hPXR[2] In Vivo Pyributicarb causes enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus[1]. References [2]. Kojima H, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280(3):77-87. Chemical & Physical Properties Molecular Formula C18H22N2O2S Exact Mass 330.140198 PSA 75.47000 Index of Refraction 1.599 InChIKey VTRWMTJQBQJKQH-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | S. Import and export pesticide registration certificate |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 United Nations shipping name European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (O-3-Tert-butylphenyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (O-3-Tert-butylphenyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (O-3-Tert-butylphenyl N-(6-methoxy-2- pyridyl)-N-methylthiocarbamate) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: Yes Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Pyrazolynate | 58011-68-0 | 2A-9012201 |
| Pyrazosulfuron-Ethyl | 93697-74-6 | 2A-9012202 |
| Pyrazoxyfen | 71561-11-0 | 2A-9012203 |
| Pyrethrin 2 | 2A-303288 | 2A-9012204 |
| Pyrethrin I | 121-21-1 | 2A-9012205 |
| Pyricarbate | 1882-26-4 | 2A-9012207 |
| Pyridaphenthion | 119-12-0 | 2A-9012209 |
| Pyriftalid | 135186-78-6 | 2A-9012211 |
| Pyrilamine | 91-84-9 | 2A-9012212 |
| Pyrimethanil | 53112-28-0 | 2A-9012213 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS