CAS Number125-65-5
SynonymsPleuromulin; Drosophilin B,Mutilin 14-glycolate; EINECS 204-747-5; 3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl glycolate
Molecular FormulaC22H34O5
Molecular Weight378.502
Purity85%
Density1.2±0.1 g/cm3
Boiling Point482.8±45.0 °C at 760 mmHg
Melting Point170-171ºC
Appearancecrystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 125-65-5 |
| Catalog No. | 2A-9012063 |
| Chinese Name | 截短侧耳素 |
| Synonyms | Pleuromulin; Drosophilin B,Mutilin 14-glycolate; EINECS 204-747-5; 3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl glycolate |
| Molecular Formula | C22H34O5 |
| Molecular Weight | 378.502 |
| Purity | 85 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 482.8±45.0 °C at 760 mmHg |
| Melting Point | 170-171ºC |
| Appearance | crystalline solid |
| Storage Condition | -20℃, protected from light, inert gas |
| Application | Pleuromutilin can inhibit bacterial protein synthesis by binding to the 50S ribosome subunit of bacteria. |
| HTC | 2918199090 |
| SMILES | C=CC1(C)CC(OC(=O)CO)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O |
| InChI | InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3 |
| InChI Key | ZRZNJUXESFHSIO-FEOSZSLTSA-N |
| MSDS | msds/12063_1_125_65_5.pdf |
| Use of | pleuromutilin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria. Properties Articles26 Name Pleuromutilin Synonym More Synonyms Pleuromutilin Biological Activity Description pleuromutilin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Terpenoids and Glycosides References [1]. Shang RF et al. Synthesis and biological evaluation of new pleuromutilin derivatives as antibacterial agents. Molecules. 2014 Nov 19;19(11):19050-65. Chemical & Physical Properties Molecular Formula C22H34O5 Exact Mass 378.240631 PSA 83.83000 Index of Refraction 1.538 InChIKey ZRZNJUXESFHSIO-FEOSZSLTSA-N SMILES C=CC1(C)CC(OC(=O)CO)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl- 3a,9- propano-3aH-cyclopentacycloocten-1(4H)-one CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C22-H34-O5 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,123,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,123,1981 Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport RTECS MC5408000 HS Code 2918199090 Synthetic Route (3S,3aR,4R,5R,7... CAS#:80878-40-6 Pleuromutilin CAS#:125-65-5 Literature: Journal of the American Chemical Society, , vol. 111, # 21 p. 8284 - 8286 (3aR,4R,5R,7S,8... CAS#:80878-41-7 Pleuromutilin CAS#:125-65-5 Literature: Journal of the American Chemical Society, , vol. 111, # 21 p. 8284 - 8286 (3R,3aS,4S,5S,7... CAS#:80878-39-3 Pleuromutilin CAS#:125-65-5 Literature: Journal of the American Chemical Society, , vol. 111, # 21 p. 8284 - 8286 |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0% |
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