CAS Number85371-64-8
SynonymsPinacidil (hydrate); Pinacidil . monohydrate; 1-Cyano-3-(3,3-dimethylbutan-2-yl)-2-pyridin-4-ylguanidine hydrate (1:1); (±)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine; MFCD00242745; Hndac; GUANIDINE,N-CYANO-N'-4-PYRIDINYL-N''-(1,2,2-TRIMETHYLPROPYL)-, HYDRATE (1:1); Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropyl)-, hydrate (1:1); Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-,monohydrate; Pinacidil monohydrate; EINECS 262-294-9; Pinacidil hydrate; 1-Cyano-2-(3,3-dimethyl-2-butanyl)-3-(4-pyridinyl)guanidine hydrate (1:1)
Molecular FormulaC13H21N5O
Molecular Weight263.34
Purity98%
Boiling Point356.7ºC at 760 mmHg
Melting Point164-165ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85371-64-8 |
| Catalog No. | 2A-9012025 |
| Chinese Name | 吡那地尔 |
| Synonyms | Pinacidil (hydrate); Pinacidil . monohydrate; 1-Cyano-3-(3,3-dimethylbutan-2-yl)-2-pyridin-4-ylguanidine hydrate (1:1); (±)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine; MFCD00242745; Hndac; GUANIDINE,N-CYANO-N'-4-PYRIDINYL-N''-(1,2,2-TRIMETHYLPROPYL)-, HYDRATE (1:1); Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropyl)-, hydrate (1:1); Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-,monohydrate; Pinacidil monohydrate; EINECS 262-294-9; Pinacidil hydrate; 1-Cyano-2-(3,3-dimethyl-2-butanyl)-3-(4-pyridinyl)guanidine hydrate (1:1) |
| Molecular Formula | C13H21N5O |
| Molecular Weight | 263.34 |
| Purity | 98 |
| Boiling Point | 356.7ºC at 760 mmHg |
| Melting Point | 164-165ºC |
| Appearance | powder |
| Water Solubility | ethanol: 14 mg/mL |
| Storage Condition | Sealed in a cool, dry environment |
| Application | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. |
| HTC | 2933399090 |
| SMILES | CC(N=C(NC#N)Nc1ccncc1)C(C)(C)C.O |
| InChI | InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2 |
| InChI Key | AFJCNBBHEVLGCZ-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/12025_1_85371_64_8.pdf |
| Bioactivity | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Others In Vitro Pinacidil monohydrate is a potassium channel activator[1]. Pinacidil hydrate is an antihypertensive drug of the class of agents called "potassium channel openers"[2]. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively[3]. References [1]. Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86. [2]. Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5. [3]. Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92. Chemical & Physical Properties Boiling Point 356.7ºC at 760 mmHg Melting Point 164-165ºC Molecular Formula C13H21N5O Molecular Weight 263.34 Flash Point 169.5ºC PSA 73.10000 LogP 2.94578 InChIKey AFJCNBBHEVLGCZ-UHFFFAOYSA-N SMILES CC(N=C(NC#N)Nc1ccncc1)C(C)(C)C.O Storage condition 2-8℃ Water Solubility ethanol: 14 mg/mL |
| Use of | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. Properties Articles29 Name Pinacidil Synonym More Synonyms Pinacidil hydrate Biological Activity Description Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Others In Vitro Pinacidil monohydrate is a potassium channel activator[1]. Pinacidil hydrate is an antihypertensive drug of the class of agents called "potassium channel openers"[2]. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively[3]. References [1]. Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86. [2]. Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5. [3]. Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92. Chemical & Physical Properties Molecular Formula C13H21N5O PSA 73.10000 LogP 2.94578 InChIKey AFJCNBBHEVLGCZ-UHFFFAOYSA-N Storage condition 2-8℃ |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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