CAS Number2207-75-2
Synonyms1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-, potassium salt (1:1); Allantoxanic acid; monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate; Potassium Oxonate; Oxonic acid potassium salt; Oxonic acid; Potassium 4,6-Dihydroxy-1,3,5-triazine-2-carboxylate; Potassium azaorotate; Oxonate; MFCD00010565; Potassium Allantoxanate; 5-Aza-orotsaeure K-Salz; potassium 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylate; Potassium 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylate; Allantoxanic Acid Potassium Salt; Oxonic acid,potassium salt; Oteracil potassium; Oxonate,potassium; EINECS 218-627-5
Molecular FormulaC4H2KN3O4
Molecular Weight195.17
Purity97%
Melting Point300 °C (lit.)
Appearanceoff-white solid
EINECS218-627-5
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2207-75-2 |
| Catalog No. | 2A-9000012 |
| Chinese Name | 氧嗪酸钾 |
| Synonyms | 1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-, potassium salt (1:1); Allantoxanic acid; monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate; Potassium Oxonate; Oxonic acid potassium salt; Oxonic acid; Potassium 4,6-Dihydroxy-1,3,5-triazine-2-carboxylate; Potassium azaorotate; Oxonate; MFCD00010565; Potassium Allantoxanate; 5-Aza-orotsaeure K-Salz; potassium 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylate; Potassium 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylate; Allantoxanic Acid Potassium Salt; Oxonic acid,potassium salt; Oteracil potassium; Oxonate,potassium; EINECS 218-627-5 |
| Molecular Formula | C4H2KN3O4 |
| Molecular Weight | 195.17 |
| Purity | 97 |
| Melting Point | 300 °C (lit.) |
| Appearance | off-white solid |
| Storage Condition | Store in a cool, dry place. Store in a closed cont |
| Application | Oxonic acid potassium salt is a uricase inhibitor that inhibits 5-FU phosphorylation to 5-fluorouridine-5 '-monophosphate. |
| EINECS | 218-627-5 |
| HTC | 2933699090 |
| PubChem ID | 24849591 |
| MDL Number | MFCD00010565 |
| SMILES | [K+].[O-]C(=O)C1=NC(=O)NC(=O)N1 |
| InChI | 1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1 |
| InChI Key | IAPCTXZQXAVYNG-UHFFFAOYSA-M |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/12_1_2207_75_2.pdf |
| Bioactivity | Oxonic acid potassium salt is an inhibitor of uricase, oxonic inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro.IC50 value: Target: On p.o. administration of 5-FU (2 mg/kg) and a potent inhibitor of 5-FU degradation to Yoshida sarcoma-bearing rats, oxonic acid (10 mg/kg) was found to inhibit the formation of 5-fluorouridine-5'-monophosphate from 5-FU and its subsequent incorporation into the RNA fractions of small and large intestine but not of tumor and bone marrow tissues [1]. Oxonic acid diet increased plasma uric acid by 80-90 micromol/l, while blood pressure was elevated only in hyperuricemic 5/6 nephrectomy rats (18 mmHg) [2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53(17):4004-9. [2]. Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26(8):1661-8. Chemical & Physical Properties Melting Point 300 °C(lit.) Molecular Formula C4H2KN3O4 Molecular Weight 195.175 Exact Mass 194.968231 PSA 118.74000 InChIKey IAPCTXZQXAVYNG-UHFFFAOYSA-M SMILES O=C([O-])c1nc(=O)[nH]c(=O)[nH]1.[K+] Storage condition Refrigerator, Under Inert Atmosphere |
| Use of | Properties Name potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate Synonym More Synonyms Potassium oxonate Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53(17):4004-9. [2]. Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26(8):1661-8. Chemical & Physical Properties Molecular Formula C4H2KN3O4 Exact Mass 194.968231 PSA 118.74000 InChIKey IAPCTXZQXAVYNG-UHFFFAOYSA-M SMILES O=C([O-])c1nc(=O)[nH]c(=O)[nH]1.[K+] Storage condition Refrigerator, Under Inert Atmosphere |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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