CAS Number526-18-1
SynonymsMFCD00020026; bilene; osalmid; bilocol; 2-Hydroxy-N-(4-hydroxyphenyl)benzamide; Qsalmid; auxobil; EINECS 208-385-9; LOIRD; 2-Hydroxy-N-(4-Hydroxy Phenyl)Benzamide; driol; phps; l1718; 4'-HYDROXYSALICYLANILIDE; Oksafenamide; enidran; N-Salicoylaminophenol
Molecular FormulaC13H11NO3
Molecular Weight229.23
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point350.8±27.0 °C at 760 mmHg
Melting Point179ºC
Appearancepowder
EINECS208-385-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 526-18-1 |
| Catalog No. | 2A-9011796 |
| Chinese Name | 柳胺酚 |
| Synonyms | MFCD00020026; bilene; osalmid; bilocol; 2-Hydroxy-N-(4-hydroxyphenyl)benzamide; Qsalmid; auxobil; EINECS 208-385-9; LOIRD; 2-Hydroxy-N-(4-Hydroxy Phenyl)Benzamide; driol; phps; l1718; 4'-HYDROXYSALICYLANILIDE; Oksafenamide; enidran; N-Salicoylaminophenol |
| Molecular Formula | C13H11NO3 |
| Molecular Weight | 229.23 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 350.8±27.0 °C at 760 mmHg |
| Melting Point | 179ºC |
| Appearance | powder |
| Storage Condition | Room Temperature |
| Application | Osalmid is a compound targeting ribonucleotide reductase small subunit M2 (RRM2); the IC50 value for inhibiting ribonucleotide reductase activity is 8.23 μM. |
| EINECS | 208-385-9 |
| HTC | 2924299090 |
| MDL Number | MFCD00020026 |
| SMILES | N(c2ccc(cc2)O)C(=O)c1c(cccc1)O |
| InChI | 1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17) |
| InChI Key | LGCMKPRGGJRYGM-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/11796_1_526_18_1.pdf |
| Bioactivity | Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 μM. Related Catalog Signaling Pathways >> Anti-infection >> HBV Research Areas >> Infection Target IC50: 8.23 μM (ribonucleotide reductase)[1] In Vitro Osalmid is identified as a potential ribonucleotide reductase small subunit M2 (RRM2) compound. Osalmid is 10-fold more active in inhibiting ribonucleotide reductase (RR) activity than hydroxyurea, and significantly inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells in a time- and dose-dependent manner. After treatment for 8 days with Osalmid, the EC50 for HBV DNA inhibition are 11.1 μM for culture supernatant and 16.5 μM for cells. Osalmid suppresses RR activity in a concentration-dependent manner, with an IC50 of 8.23 μM. Osalmid is shown to possess potent activity against a 3TC-resistant HBV strain, suggesting utility in treating drug-resistant HBV infections[1]. In Vivo Osalmid reduces RR activity and HBV replication in HBV-transgenic mice and shows a synergistic efficacy with 3TC without significant toxicity. Oral dosing of osalmid at 400 mg/kg/d results in a time-dependent inhibition of HBV DNA replication. After treatment for 4 weeks, osalmid suppresses HBV DNA replication by about 40-45% as compared to the control in mouse sera and liver tissues[1]. Cell Assay HepG2.2.15 cells are cultured in the presence of 200 μg/mL G418. Cell viability is determined using a Cell Counting Kit-8 in 96-well plates treated with Osalmid for designated times. For long term assays, the culture supernatants are replaced with fresh media containing Osalmid every two days. The control wells contained equivalent amounts of DMSO. The CC50 is calculated as the concentration of a compound that reduced the cell viability to 50% compared to the control[1]. Animal Admin Mice: The HBV-transgenic mouse lineage is initially produced on a BALB/c background. Osalmid or 3TC is suspended in 0.05% CMC-Na and administered once a day by gavage at 400 and 100 mg/kg, respectively, for 28 days. For the combination group, mice are intragastrically administered with a mixture of osalmid and 3TC. 0.05% CMC-Na solution is used as control. The mouse sera are collected and assayed for HBV DNA levels and AST/ALT activity. Mice are then sacrificed after the 28-day drug treatment and the livers are excised for analysis[1]. References [1]. Liu X, et al. Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. Biochem Pharmacol. 2016 Mar 1;103:118-28. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 350.8±27.0 °C at 760 mmHg Melting Point 179ºC Molecular Formula C13H11NO3 Molecular Weight 229.231 Flash Point 165.9±23.7 °C Exact Mass 229.073898 PSA 69.56000 LogP 2.53 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.711 InChIKey LGCMKPRGGJRYGM-UHFFFAOYSA-N SMILES O=C(Nc1ccc(O)cc1)c1ccccc1O |
| Use of | Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 μM. Properties Name 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide Synonym More Synonyms osalmid Biological Activity Description Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 μM. Related Catalog Signaling Pathways >> Anti-infection >> HBV Research Areas >> Infection IC50: 8.23 μM (ribonucleotide reductase)[1] References [1]. Liu X, et al. Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. Biochem Pharmacol. 2016 Mar 1;103:118-28. Chemical & Physical Properties Molecular Formula C13H11NO3 Exact Mass 229.073898 PSA 69.56000 Index of Refraction 1.711 InChIKey LGCMKPRGGJRYGM-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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