CAS Number6981-18-6
SynonymsUNII-M3EFS94984; 5-((4,5-Dimethoxy-2-methylphenyl)methyl)-2,4-pyrimidinediamine; Ro 5-9754; component of Rofenaid; EINECS 230-246-6; MFCD00057747; 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4(1H,3H)-pyrimidinediimine; 5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine; 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4-pyrimidinediamine; Ormethoprim; Ormetorprim
Molecular FormulaC14H18O2N4
Molecular Weight274.32
Purity98%
Density1.3±0.1 g/cm3
Boiling Point398.2±52.0 °C at 760 mmHg
Melting Point233°C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6981-18-6 |
| Catalog No. | 2A-9011789 |
| Chinese Name | 奥美普林 |
| Synonyms | UNII-M3EFS94984; 5-((4,5-Dimethoxy-2-methylphenyl)methyl)-2,4-pyrimidinediamine; Ro 5-9754; component of Rofenaid; EINECS 230-246-6; MFCD00057747; 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4(1H,3H)-pyrimidinediimine; 5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine; 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4-pyrimidinediamine; Ormethoprim; Ormetorprim |
| Molecular Formula | C14H18O2N4 |
| Molecular Weight | 274.32 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 398.2±52.0 °C at 760 mmHg |
| Melting Point | 233°C |
| Storage Condition | 0-6°C |
| Application | Ormetoprim is a veterinary antimicrobial agent commonly used in the aquaculture and poultry industries. Ormetoprim is used to prevent the spread of disease in freshwater aquaculture and to promote the |
| MDL Number | MFCD00057747 |
| SMILES | COc1cc(C)c(Cc2cnc(N)nc2N)cc1OC |
| InChI | InChI=1S/C14H18N4O2/c1-8-4-11(19-2)12(20-3)6-9(8)5-10-7-17-14(16)18-13(10)15/h4,6-7H,5H2,1-3H3,(H4,15,16,17,18) |
| InChI Key | KEEYRKYKLYARHO-UHFFFAOYSA-N |
| MSDS | msds/11789_1_6981_18_6.pdf |
| Bioactivity | Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2]. Related Catalog Research Areas >> Infection In Vivo Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL)[3]. Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration[3]. Animal Model: Hybrid striped bass (565-805 g)[3] Dosage: 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis) Administration: I.p. and p.o. administration Result: I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL. P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%. References [1]. Sanders SM, et, al. Sorption of the veterinary antimicrobials sulfadimethoxine and ormetoprim in soil. J Environ Qual. 2008 Jun 23; 37(4): 1510-8. [2]. Guerard JJ, et, al. Photodegradation of ormetoprim in aquaculture and stream-derived dissolved organic matter. J Agric Food Chem. 2012 Oct 3; 60(39): 9801-6. [3]. Bakal RS, et, al. Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis). J Vet Pharmacol Ther. 2004 Feb; 27(1): 1-6. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 398.2±52.0 °C at 760 mmHg Melting Point 233°C Molecular Formula C14H18N4O2 Molecular Weight 274.318 Flash Point 194.6±30.7 °C Exact Mass 274.142975 PSA 96.28000 LogP 1.13 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.608 InChIKey KEEYRKYKLYARHO-UHFFFAOYSA-N SMILES COc1cc(C)c(Cc2cnc(N)nc2N)cc1OC Storage condition 0-6°C |
| Use of | Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2]. Properties Name 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine Synonym More Synonyms Ormetoprim Biological Activity Description Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2]. Related Catalog Research Areas >> Infection References [1]. Sanders SM, et, al. Sorption of the veterinary antimicrobials sulfadimethoxine and ormetoprim in soil. J Environ Qual. 2008 Jun 23; 37(4): 1510-8. [2]. Guerard JJ, et, al. Photodegradation of ormetoprim in aquaculture and stream-derived dissolved organic matter. J Agric Food Chem. 2012 Oct 3; 60(39): 9801-6. [3]. Bakal RS, et, al. Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis). J Vet Pharmacol Ther. 2004 Feb; 27(1): 1-6. Chemical & Physical Properties Molecular Formula C14H18N4O2 Exact Mass 274.142975 PSA 96.28000 Index of Refraction 1.608 InChIKey KEEYRKYKLYARHO-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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