CAS Number65141-46-0
SynonymsNitorubin; Perisalol; 2-(pyridine-3-carbonylamino)ethyl nitrate; 2-[(Pyridin-3-ylcarbonyl)amino]ethylnitrat; Nicorandil; Ikorel; SG-75; Dancor; EINECS 265-514-1; Nikoran; Nicorandilum; 2-[(Pyridin-3-ylcarbonyl)amino]ethyl nitrate; N-(2-hydroxyethyl)nicotinamide nitrate ester; 2-[(3-Pyridinylcarbonyl)amino]ethyl nitrate; Adancor; N-[2-(nitroxy)ethyl]-3-pyridine carboxamide; Sigmart; 2-Nicotinamidoethyl nitrate
Molecular FormulaC8H9N3O4
Molecular Weight211.17
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point456.7±25.0 °C at 760 mmHg
Melting Point92ºC
Appearancepowder
EINECS265-514-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 65141-46-0 |
| Catalog No. | 2A-9011644 |
| Chinese Name | 尼可地尔 |
| Synonyms | Nitorubin; Perisalol; 2-(pyridine-3-carbonylamino)ethyl nitrate; 2-[(Pyridin-3-ylcarbonyl)amino]ethylnitrat; Nicorandil; Ikorel; SG-75; Dancor; EINECS 265-514-1; Nikoran; Nicorandilum; 2-[(Pyridin-3-ylcarbonyl)amino]ethyl nitrate; N-(2-hydroxyethyl)nicotinamide nitrate ester; 2-[(3-Pyridinylcarbonyl)amino]ethyl nitrate; Adancor; N-[2-(nitroxy)ethyl]-3-pyridine carboxamide; Sigmart; 2-Nicotinamidoethyl nitrate |
| Molecular Formula | C8H9N3O4 |
| Molecular Weight | 211.17 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 456.7±25.0 °C at 760 mmHg |
| Melting Point | 92ºC |
| Appearance | powder |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Nicorandil potassium channel activator. |
| EINECS | 265-514-1 |
| HTC | 2933399090 |
| PubChem ID | 329818637 |
| MDL Number | MFCD00186520 |
| SMILES | [O-][N+](=O)OCCNC(=O)c1cccnc1 |
| InChI | 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12) |
| InChI Key | LBHIOVVIQHSOQN-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/11644_1_65141_46_0.pdf |
| Bioactivity | Nicorandil is potassium channel activator.Target: Potassium ChannelNicorandil is a vasodilatory drug used to treat angina. Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle. PKG also activates the sarcolemma calcium pump to remove activating calcium. PKG acts on K+ channels to promote K+ efflux and the ensuing hyperpolarization inhibits voltage-gated calcium channels. Overall, this leads to relaxation of the smooth muscle and coronary vasodilation [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25. [2]. Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 456.7±25.0 °C at 760 mmHg Melting Point 92ºC Molecular Formula C8H9N3O4 Molecular Weight 211.175 Flash Point 230.0±23.2 °C Exact Mass 211.059311 PSA 97.04000 LogP 0.72 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.548 InChIKey LBHIOVVIQHSOQN-UHFFFAOYSA-N SMILES O=C(NCCO[N+](=O)[O-])c1cccnc1 Storage condition 2-8°C |
| Use of | Nicorandil is potassium channel activator.Target: Potassium ChannelNicorandil is a vasodilatory drug used to treat angina. Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle. PKG also activates the sarcolemma calcium pump to remove activating calcium. PKG acts on K+ channels to promote K+ efflux and the ensuing hyperpolarization inhibits voltage-gated calcium channels. Overall, this leads to relaxation of the smooth muscle and coronary vasodilation [1, 2]. Properties Articles51 Name nicorandil Synonym More Synonyms Nicorandil Biological Activity Description Nicorandil is potassium channel activator.Target: Potassium ChannelNicorandil is a vasodilatory drug used to treat angina. Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle. PKG also activates the sarcolemma calcium pump to remove activating calcium. PKG acts on K+ channels to promote K+ efflux and the ensuing hyperpolarization inhibits voltage-gated calcium channels. Overall, this leads to relaxation of the smooth muscle and coronary vasodilation [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25. [2]. Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9. Chemical & Physical Properties Molecular Formula C8H9N3O4 Exact Mass 211.059311 PSA 97.04000 Index of Refraction 1.548 InChIKey LBHIOVVIQHSOQN-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
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