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Nefiracetam structure, CAS 77191-36-7

Nefiracetam

CAS Number77191-36-7

SynonymsN-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide; Nefiracetam; MFCD00209882; Dmmpa; 2-(2-Oxo-1-pyrrolidinyl)-N-(2,6-dimethylphenyl)acetamide; N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide

Molecular FormulaC14H18N2O2

Molecular Weight246.30

Purity98%

Density1.2±0.1 g/cm3

Boiling Point458.5±33.0 °C at 760 mmHg

Melting Point151-155°C

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

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Cat. No.: 2A-9011600 Purity: 98%
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Quality Control of [ 77191-36-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number77191-36-7
Catalog No.2A-9011600
Chinese Name奈非西坦
SynonymsN-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide; Nefiracetam; MFCD00209882; Dmmpa; 2-(2-Oxo-1-pyrrolidinyl)-N-(2,6-dimethylphenyl)acetamide; N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide
Molecular FormulaC14H18N2O2
Molecular Weight246.30
Purity98
Density1.2±0.1 g/cm3
Boiling Point458.5±33.0 °C at 760 mmHg
Melting Point151-155°C
Appearancesolid
Storage ConditionStore at RT
ApplicationNefiracetam acts on convulsions caused by Ro 5-4864 and is a GABAergic, choline and monoamine nervous system enhancer.
HTC2933790090
PubChem ID329818410
MDL NumberMFCD00209882
SMILESCc1cccc(C)c1NC(=O)CN2CCCC2=O
InChI1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChI KeyNGHTXZCKLWZPGK-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/11600_1_77191_36_7.pdf
BioactivityNefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.Target: GABA ReceptorNefiracetam induces a short-term depression of ACh-evoked currents at submicromolar concentrations (0.01-0.1 μM) and a long-term enhancement of the currents at micromolar concentrations (1-10 μM). Nefiracetam interacts with PKA and PKC pathways, which may explain a cellular mechanism for the action of cognition-enhancing agents. Lower (submicromolar) concentrations of the nootropic Nefiracetam reduces ACh-evoked currents to 30% (0.01 μM) and 38% (0.1 μM) of control after a 10-minute treatment [1].Nefiracetam administered orally inhibits Ro 5-4864-induced convulsions in EL mice. Nefiracetam also efficiently inhibits Ro 5-4864-induced convulsions in DDY mice at doses higher than 10 mg/kg [2]. Nefiracetam administered daily 1 hour before each training session facilitates the acquisition process of the avoidance response [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Nishizaki, T., et al., Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways. Mol Pharmacol, 1998. 53(1): p. 1-5. [2]. Shiotani, T., et al., Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res, 2000. 859(2): p. 255-61. [3]. Sakurai, T., et al., Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats. Jpn J Pharmacol, 1989. 50(1): p. 47-53. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 458.5±33.0 °C at 760 mmHg Melting Point 151-155°C Molecular Formula C14H18N2O2 Molecular Weight 246.305 Flash Point 231.1±25.4 °C Exact Mass 246.136826 PSA 49.41000 LogP 1.53 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.594 InChIKey NGHTXZCKLWZPGK-UHFFFAOYSA-N SMILES Cc1cccc(C)c1NC(=O)CN1CCCC1=O Storage condition Store at RT
Use ofProperties Articles28 Name N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide Synonym More Synonyms Nefiracetam Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Nishizaki, T., et al., Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways. Mol Pharmacol, 1998. 53(1): p. 1-5. [2]. Shiotani, T., et al., Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res, 2000. 859(2): p. 255-61. [3]. Sakurai, T., et al., Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats. Jpn J Pharmacol, 1989. 50(1): p. 47-53. Chemical & Physical Properties Molecular Formula C14H18N2O2 Exact Mass 246.136826 PSA 49.41000 Index of Refraction 1.594 InChIKey NGHTXZCKLWZPGK-UHFFFAOYSA-N Storage condition Store at RT
Tax Rebate9.0%
SupervisionNone MFN tariff: 9.0% Ordinary tariff: 20.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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