CAS Number1508-75-4
SynonymsN-Ethyl-N-(g-picolyl)tropamide; 8-Methyl-8-azabicyclo[3.2.1]octan-3-ol; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide; Tropine; endo-Tropanol; TROPAN-3ALPHA-OL; 3alpha-Tropanol; N-Ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide; N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide; N-Ethyl-N-(4-pyridylmethyl)tropamide; N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide; EINECS 216-140-2; Tropicamide; Mydriacyl; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683,Tropicamide; UNII:N0A3Z5XTC6; endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol; tropinol; MFCD00058580; 3-TROPANOL; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683; TROPANOL
Molecular FormulaC17H20N2O2
Molecular Weight284.35
Purity99%
Density1.2±0.1 g/cm3
Boiling Point492.8±45.0 °C at 760 mmHg
Melting Point98 °C
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1508-75-4 |
| Catalog No. | 2A-9011532 |
| Chinese Name | 托吡卡胺 |
| Synonyms | N-Ethyl-N-(g-picolyl)tropamide; 8-Methyl-8-azabicyclo[3.2.1]octan-3-ol; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide; Tropine; endo-Tropanol; TROPAN-3ALPHA-OL; 3alpha-Tropanol; N-Ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide; N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide; N-Ethyl-N-(4-pyridylmethyl)tropamide; N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide; EINECS 216-140-2; Tropicamide; Mydriacyl; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683,Tropicamide; UNII:N0A3Z5XTC6; endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol; tropinol; MFCD00058580; 3-TROPANOL; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683; TROPANOL |
| Molecular Formula | C17H20N2O2 |
| Molecular Weight | 284.35 |
| Purity | 99 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 492.8±45.0 °C at 760 mmHg |
| Melting Point | 98 °C |
| Appearance | white powder |
| Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 m |
| Storage Condition | Sealed, stored at 2ºC -8ºC |
| Application | Tropicamide is an anticholinergic and muscarinic receptor M4 subtype antagonist. |
| HTC | 2933399090 |
| MDL Number | MFCD00058580 |
| SMILES | CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2 |
| InChI | 1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3 |
| InChI Key | BGDKAVGWHJFAGW-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/11532_1_1508_75_4.pdf |
| Bioactivity | Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15. [2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 492.8±45.0 °C at 760 mmHg Melting Point 98 °C Molecular Formula C17H20N2O2 Molecular Weight 284.353 Flash Point 251.8±28.7 °C Exact Mass 284.152466 PSA 53.43000 LogP 1.15 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.586 InChIKey BGDKAVGWHJFAGW-UHFFFAOYSA-N SMILES CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1 Storage condition 2-8°C Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL |
| Use of | Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3]. Properties Articles128 Name Tropicamide Synonym More Synonyms Tropicamide Biological Activity Description Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20. Chemical & Physical Properties Molecular Formula C17H20N2O2 Exact Mass 284.152466 PSA 53.43000 Index of Refraction 1.586 InChIKey BGDKAVGWHJFAGW-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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