CAS Number135410-20-7
Synonyms(1E)-N-[(6-chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide; (E)-N-[(6-Chloropyridin-3-yl)methyl]-N'-cyano-N-methylacetimidamide; (E)-N1-[(6-Chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine; (E)-N-((6-Chloropyridin-3-yl)methyl)-N'-cyano-N-methylacetimidamide; acetamiprid; (1E)-N-[(6-Chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide; (E)-N-(6-Chloro-3-pyridylmethyl)-N'-cyano-N-methylacetamidine; (E)-N-[(6-Chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide; (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide; N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide; MFCD06201842; (1E)-N-[(6-Chlorpyridin-3-yl)methyl]-N'-cyan-N-methylethanimidamid; T6NJ BG E1N1Y1&UNCN &&E Form; (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methyleth
Molecular FormulaC10H11N4Cl1
Molecular Weight222.68
Purity98%
Density1.2±0.1 g/cm3
Boiling Point352.4±52.0 °C at 760 mmHg
Melting Point101-103ºC
Appearancewhite powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 135410-20-7 |
| Catalog No. | 2A-9011510 |
| Chinese Name | 啶虫脒 |
| Synonyms | (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide; (E)-N-[(6-Chloropyridin-3-yl)methyl]-N'-cyano-N-methylacetimidamide; (E)-N1-[(6-Chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine; (E)-N-((6-Chloropyridin-3-yl)methyl)-N'-cyano-N-methylacetimidamide; acetamiprid; (1E)-N-[(6-Chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide; (E)-N-(6-Chloro-3-pyridylmethyl)-N'-cyano-N-methylacetamidine; (E)-N-[(6-Chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide; (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide; N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide; MFCD06201842; (1E)-N-[(6-Chlorpyridin-3-yl)methyl]-N'-cyan-N-methylethanimidamid; T6NJ BG E1N1Y1&UNCN &&E Form; (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methyleth |
| Molecular Formula | C10H11N4Cl1 |
| Molecular Weight | 222.68 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 352.4±52.0 °C at 760 mmHg |
| Melting Point | 101-103ºC |
| Appearance | white powder |
| Storage Condition | 0-6°C |
| Packaging | III |
| Application | Acetamiprid is a widely used neonicotinoid insecticide. Acetamiprid is an nAChR agonist associated with neuromuscular and reproductive disorders. |
| HTC | 2933399022 |
| MDL Number | MFCD06201842 |
| SMILES | CN(Cc1ccc(Cl)nc1)C(C)=NC#N |
| InChI | InChI=1S/C10H11ClN4/c1-8(14-7-12)15(2)6-9-3-4-10(11)13-5-9/h3-5H,6H2,1-2H3 |
| InChI Key | InChIKey=WCXDHFDTOYPNIE-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11510_1_135410_20_7.pdf |
| Bioactivity | Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease Target nAChR[1] In Vivo Acetamiprid decreases in body weight and mildly affected spermatogenesis. [1]. Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice[1]. Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats[2]. Animal Model: Male Sprague Dawley (SD) rats[2] Dosage: 10 mg/kg, 30 mg/kg Administration: Oral gavage; daily; for 35 days Result: Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells. References [1]. Terayama H, et al. Effect of acetamiprid on the immature murine testes. Int J Environ Health Res. 2018 Dec;28(6):683-696. [2]. Kong D, et al. Acetamiprid inhibits testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells. Biol Reprod. 2017 Jan 1;96(1):254-265. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 352.4±52.0 °C at 760 mmHg Melting Point 101-103ºC Molecular Formula C10H11ClN4 Molecular Weight 222.674 Flash Point 166.9±30.7 °C Exact Mass 222.067230 PSA 52.28000 LogP 0.62 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.571 Storage condition 0-6°C |
| Use of | Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders[1][2]. Properties Articles11 Name (E)-acetamiprid Synonym More Synonyms Acetamiprid Biological Activity Description Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Terayama H, et al. Effect of acetamiprid on the immature murine testes. Int J Environ Health Res. 2018 Dec;28(6):683-696. [2]. Kong D, et al. Acetamiprid inhibits testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells. Biol Reprod. 2017 Jan 1;96(1):254-265. Chemical & Physical Properties Exact Mass 222.067230 PSA 52.28000 Index of Refraction 1.571 |
| Tax Rebate | 9.0% |
| Supervision | S. Import and export pesticide registration certificate |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Acetamiprid) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Acetamiprid) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Acetamiprid) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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