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Moracizine hydrochloride structure, CAS 29560-58-5

Moracizine hydrochloride

CAS Number29560-58-5

SynonymsMoracizin-HCl; ethmozoine hydrochloride; Etmozin; Moricizine HCl; Ethmosine; UNII-71OK3Z1ESP; Ethmozin; ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate,hydrochloride; Moracizine hydrochloride; EN 313; MORICIZINE HYDROCHLORIDE; Ethmozine

Molecular FormulaC22H26ClN3O4S

Molecular Weight463.98

Purity98%

Density

Boiling Point625ºC at 760 mmHg

Melting Point

Flash Point

AppearanceWhite to yellowish brown crystalline powder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9011502 Purity: 98%
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Quality Control of [ 29560-58-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number29560-58-5
Catalog No.2A-9011502
Chinese Name盐酸莫雷西嗪
SynonymsMoracizin-HCl; ethmozoine hydrochloride; Etmozin; Moricizine HCl; Ethmosine; UNII-71OK3Z1ESP; Ethmozin; ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate,hydrochloride; Moracizine hydrochloride; EN 313; MORICIZINE HYDROCHLORIDE; Ethmozine
Molecular FormulaC22H26ClN3O4S
Molecular Weight463.98
Purity98
Boiling Point625ºC at 760 mmHg
AppearanceWhite to yellowish brown crystalline powder
ApplicationMoricizine hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine hydrochloride reduces the maximum rate of phase 0 depolarization; increases the rate of phase 2 and 3 rep
HTC2934999090
MDL NumberMFCD01100224
SMILESS1c2c(cc(cc2)NC(=O)OCC)N(c4c1cccc4)C(=O)CC[N+H]3CCOCC3.[Cl-]
InChI1S/C22H25N3O4S.ClH/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24;/h3-8,15H,2,9-14H2,1H3,(H,23,27);1H
InChI KeyGAQAKFHSULJNAK-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/11502_1_29560_58_5.pdf
Use ofMoricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1]. Properties Name moricizine hydrochloride Synonym More Synonyms MORACIZINE HYDROCHLORIDE Biological Activity Description Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others References [1]. Bigger JT Jr. Cardiac electrophysiologic effects of moricizine hydrochloride. Am J Cardiol. 1990 Feb 20;65(8):15D-20D; discussion 68D-71D. Chemical & Physical Properties Exact Mass 463.13300 PSA 96.41000 LogP 4.98450 InChIKey GAQAKFHSULJNAK-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester, hydrochloride CAS REGISTRY NUMBER : 29560-58-5 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C22-H25-N3-O4-S.Cl-H MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C666 BN ISJ EMVO2 B2V- AT6N DOTJ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(1),60,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,74,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,640,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(5),43,1985 Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page ETHYL 10-(B-CHL... CAS#:34749-22-9 MORACIZINE HYDR... CAS#:29560-58-5 Literature: Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488 morpholine CAS#:110-91-8 CAS#:94989-94-3 MORACIZINE HYDR... CAS#:29560-58-5 Literature: Gritsenko, A. N.; Skoldinov, A. P. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 4 p. 485 - 488 ethyl phenothia... CAS#:37711-29-8 MORACIZINE HYDR... CAS#:29560-58-5 Literature: Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488 Precursor & DownStream Precursor 3 CAS#:110-91-8 morpholine CAS#:34749-22-9 ETHYL 10-(B-CHL... CAS#:37711-29-8 ethyl phenothia... DownStream 0
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Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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