CAS Number71320-77-9
Synonyms4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide; Moclamide; moclbemide; Manefix; Moclobemide; aurorix; 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide; 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide; MFCD00865388; Moclobemidum; MODOBEMDE; ro11-1163; Moclaime; p-Chloro-N-(2-morpholinoethyl)benzamide; UNII-PJ0Y7AZB63; manerix; Moclamine
Molecular FormulaC13H17ClN2O2
Molecular Weight268.74
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point447.7±40.0 °C at 760 mmHg
Melting Point137°C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 71320-77-9 |
| Catalog No. | 2A-9011478 |
| Chinese Name | 吗氯贝胺 |
| Synonyms | 4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide; Moclamide; moclbemide; Manefix; Moclobemide; aurorix; 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide; 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide; MFCD00865388; Moclobemidum; MODOBEMDE; ro11-1163; Moclaime; p-Chloro-N-(2-morpholinoethyl)benzamide; UNII-PJ0Y7AZB63; manerix; Moclamine |
| Molecular Formula | C13H17ClN2O2 |
| Molecular Weight | 268.74 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 447.7±40.0 °C at 760 mmHg |
| Melting Point | 137°C |
| Appearance | solid |
| Storage Condition | Room temp |
| Packaging | III |
| Application | Moclobemide (Ro111163) is a reversible monoamine oxidase (MAO) inhibitor with an IC50 of 6.1 μM and can act on major depression. |
| PubChem ID | 329817960 |
| MDL Number | MFCD00865388 |
| SMILES | Clc1ccc(cc1)C(=O)NCCN2CCOCC2 |
| InChI | 1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17) |
| InChI Key | YHXISWVBGDMDLQ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11478_1_71320_77_9.pdf |
| Bioactivity | Moclobemide(Ro111163) is a reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.Target: Monoamine OxidaseMoclobemide orally administered 2 hours before decapitation preferentially inhibits MAO-A and PEA in rat brain with ED50 of 7.6 μmol/kg and 78 μmol/kg, respectively. Moclobemide orally administered 2 hours before decapitation preferentially inhibits MAO-A and PEA in rat liver with ED50 of 8.4 μmol/kg and 6.6 μmol/kg, respectively. Moclobemide (0.1 mM), which inhibits brain MAO-A activity by over 80%, does not affect benzylamine oxidase (rat heart) and diamine oxidase (rat small intestine) activity in vitro [1]. Moclobemide (10 mM-100 mM) includes in the culture medium during anoxia or with glutamate significantly increases in a concentration-dependent manner the amount of surviving neurons compared to controls in neuronal-astroglial cultures from rat cerebral cortex [2].Moclobemide (10 mg/kg p.o.) induces a significant decrease of all monoamine metabolites measured in rat brain [1]. Moclobemide, given via the drinking water (4.5 mg/kg/day), produces significant decreases in adrenal weight of rats after 5 (-23%) and 7 weeks (-16%) of treatment. Moclobemide upregulates hippocampal mineralocorticoid receptor (MR) levels in rats by 65%, 76% and 19% at 2 weeks, 5 weeks and 7 weeks of treatment, and upregulates Glucocorticoid receptor (GR) levels in this limbic brain structure by 10% at 5 weeks. Moclobemide treatment (5 weeks, 4.5 mg/kg/day) significantly attenuates stress (30 min novel environment)-induced plasma ACTH (-35%) and corticosterone (-29%) levels [3]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease References [1]. Da Prada, M., et al., Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. J Pharmacol Exp Ther, 1989. 248(1): p. 400-14. [2]. Verleye, M., et al., Moclobemide attenuates anoxia and glutamate-induced neuronal damage in vitro independently of interaction with glutamate receptor subtypes. Brain Res, 2007. 1138: p. 30-8. [3]. Reul, J.M., et al., Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology, 1994. 60(5): p. 509-19. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 447.7±40.0 °C at 760 mmHg Melting Point 137°C Molecular Formula C13H17ClN2O2 Molecular Weight 268.739 Flash Point 224.6±27.3 °C Exact Mass 268.097870 PSA 41.57000 LogP 0.84 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.550 InChIKey YHXISWVBGDMDLQ-UHFFFAOYSA-N SMILES O=C(NCCN1CCOCC1)c1ccc(Cl)cc1 Storage condition Room temp |
| Use of | Properties Articles47 Name moclobemide Synonym More Synonyms Moclobemide Biological Activity Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease References [1]. Da Prada, M., et al., Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. J Pharmacol Exp Ther, 1989. 248(1): p. 400-14. [2]. Verleye, M., et al., Moclobemide attenuates anoxia and glutamate-induced neuronal damage in vitro independently of interaction with glutamate receptor subtypes. Brain Res, 2007. 1138: p. 30-8. [3]. Reul, J.M., et al., Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology, 1994. 60(5): p. 509-19. Chemical & Physical Properties Exact Mass 268.097870 PSA 41.57000 Index of Refraction 1.550 InChIKey YHXISWVBGDMDLQ-UHFFFAOYSA-N Storage condition Room temp |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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