CAS Number72-33-3
Synonyms(17b)-17-ethynyl-3-methoxyestra-1,3,5(10)-trien-17-ol; SC 4725; d-MVE; Ovastol; 17a-Ethynylestradiol 3-Methyl Ether; EINECS 200-777-8; 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether; Devocin; (17a)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol; RS 1044; δ-MVE; (17α)-3-Methoxy-19-norpregna-1(10),2,4-trien-20-yn-17-ol; mestranol; Norquen; 17a-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-ol; MFCD00003689; 17α-Ethynylestradiol 3-methyl ether; 3-Methoxy-19-nor-17α-pregna-1,3,5(10)-trien-20-yn-17-ol
Molecular FormulaC21H26O2
Molecular Weight310.44
Purity98%
Density1.2±0.1 g/cm3
Boiling Point442.3±45.0 °C at 760 mmHg
Melting Point153-155 °C(lit.)
Appearancecrystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 72-33-3 |
| Catalog No. | 2A-9011356 |
| Chinese Name | 美雌醇 |
| Synonyms | (17b)-17-ethynyl-3-methoxyestra-1,3,5(10)-trien-17-ol; SC 4725; d-MVE; Ovastol; 17a-Ethynylestradiol 3-Methyl Ether; EINECS 200-777-8; 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether; Devocin; (17a)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol; RS 1044; δ-MVE; (17α)-3-Methoxy-19-norpregna-1(10),2,4-trien-20-yn-17-ol; mestranol; Norquen; 17a-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-ol; MFCD00003689; 17α-Ethynylestradiol 3-methyl ether; 3-Methoxy-19-nor-17α-pregna-1,3,5(10)-trien-20-yn-17-ol |
| Molecular Formula | C21H26O2 |
| Molecular Weight | 310.44 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 442.3±45.0 °C at 760 mmHg |
| Melting Point | 153-155 °C(lit.) |
| Appearance | crystalline solid |
| Water Solubility | Water solubility: insoluble; soluble in: chlorofor |
| Storage Condition | This product should be sealed, cool, dry and prote |
| Application | Mestranol acts on estrogen receptors. |
| MDL Number | MFCD06738111 |
| SMILES | C#CC1(O)CCC2C3CCc4cc(OC)ccc4C3CCC21C |
| InChI | InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3/t17-,18-,19+,20+,21+/m1/s1 |
| InChI Key | IMSSROKUHAOUJS-MJCUULBUSA-N |
| MSDS | msds/11356_1_72_33_3.pdf |
| Bioactivity | Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.Target: Estrogen Receptor/ERRMestranol is absorbed very rapidly from the digestive tract and maximum plasma levels are attained in 1-4 hours, the majority at 1-2 hours. Detectable levels of mestranol are present 24 hours postingestion in 58% of subjects after a 50 μg dose and in 79% after a 100 μg dose. At all dose levels, highest plasma mestranol levels and area under the curve of plasma levels (AUC) occurred in Sri Lankan women, and lowest plasma levels in Nigerian women, even when corrected for body surface differences [1]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology References [1]. Goldzieher, J.W., T.S. Dozier, and A. de la Pena, Plasma levels and pharmacokinetics of ethynyl estrogens in various populations: II. Mestranol. Contraception, 1980. 21(1): p. 17-27. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 442.3±45.0 °C at 760 mmHg Melting Point 153-155 °C(lit.) Molecular Formula C21H26O2 Molecular Weight 310.430 Flash Point 190.8±23.0 °C Exact Mass 310.193268 PSA 29.46000 LogP 5.17 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.591 InChIKey IMSSROKUHAOUJS-MJCUULBUSA-N SMILES C#CC1(O)CCC2C3CCc4cc(OC)ccc4C3CCC21C Storage condition -20°C Freezer |
| Use of | Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.Target: Estrogen Receptor/ERRMestranol is absorbed very rapidly from the digestive tract and maximum plasma levels are attained in 1-4 hours, the majority at 1-2 hours. Detectable levels of mestranol are present 24 hours postingestion in 58% of subjects after a 50 μg dose and in 79% after a 100 μg dose. At all dose levels, highest plasma mestranol levels and area under the curve of plasma levels (AUC) occurred in Sri Lankan women, and lowest plasma levels in Nigerian women, even when corrected for body surface differences [1]. Properties Articles33 Name mestranol Synonym More Synonyms mestranol Biological Activity Description Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.Target: Estrogen Receptor/ERRMestranol is absorbed very rapidly from the digestive tract and maximum plasma levels are attained in 1-4 hours, the majority at 1-2 hours. Detectable levels of mestranol are present 24 hours postingestion in 58% of subjects after a 50 μg dose and in 79% after a 100 μg dose. At all dose levels, highest plasma mestranol levels and area under the curve of plasma levels (AUC) occurred in Sri Lankan women, and lowest plasma levels in Nigerian women, even when corrected for body surface differences [1]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology References [1]. Goldzieher, J.W., T.S. Dozier, and A. de la Pena, Plasma levels and pharmacokinetics of ethynyl estrogens in various populations: II. Mestranol. Contraception, 1980. 21(1): p. 17-27. Chemical & Physical Properties Molecular Formula C21H26O2 Exact Mass 310.193268 PSA 29.46000 Index of Refraction 1.591 InChIKey IMSSROKUHAOUJS-MJCUULBUSA-N |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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