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2-(1-PROPYL-4-PIPERIDINYL)-1H-BENZIMIDAZOLE-7-CARBOXAMIDEBUTANEDIOIC ACID

Name: 2-(1-PROPYL-4-PIPERIDINYL)-1H-BENZIMIDAZOLE-7-CARBOXAMIDEBUTANEDIOIC ACID
Brand: 2A Biotech
SKU: 2A-0113297

CAS Number943650-25-7

Molecular FormulaC20H28N4O5

Molecular Weight404.46

Purity96+%

EINECS0

MSDSChinese English

Cat. No.: 2A-0113297 Purity: 96+%

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Quality Control of [ 943650-25-7 ] Purity: 96+% SDS Specification MoL

Chemical & Physical Properties
CAS Number	943650-25-7
Catalog No.	2A-0113297
Chinese Name	2-(1-丙基-4-哌啶基)-1H-苯并咪唑-7-羧酰胺丁二酸
Molecular Formula	C20H28N4O5
Molecular Weight	404.46
Purity	96+
Application	A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against PARP-1 enzyme, with a Ki value of
EINECS	0
HTC	2934999090
UN(IATA)	0
SMILES	CCCN1CCC(c2nc3c(C(N)=O)cccc3[nH]2)CC1.O=C(O)CCC(=O)O
InChI Key	GWFBXGWIRCSOAO-UHFFFAOYSA-N
Use of	A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1]. Properties Name butanedioic acid,2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide A-620223 Biological Activity Description A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP References [1]. Penning TD, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75. Chemical & Physical Properties Molecular Formula C20H28N4O5 Exact Mass 404.20600 PSA 150.60000 LogP 3.00910 InChIKey GWFBXGWIRCSOAO-UHFFFAOYSA-N Safety Information HS Code 2934999090
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-(1-PROPYL-4-PIPERIDINYL)-1H-BENZIMIDAZOLE-7-CARBOXAMIDEBUTANEDIOIC ACID

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