CAS Number61-68-7
SynonymsPonstyl; Pontal; Parkemed; Mefenacid; Mefenamate; EINECS 200-513-1; Lysalgo; MFCD00051721; Ponalar; Mefenamic acid; 2-[(2,3-Dimethylphenyl)amino]benzoic acid; Ponstel; N-(2,3-Xylyl)anthranilic acid; Ponstan
Molecular FormulaC15H15NO2
Molecular Weight241.29
Purity99.00%
Density1.2±0.1 g/cm3
Boiling Point398.8±30.0 °C at 760 mmHg
Melting Point230 °C
AppearanceLight yellow solid
EINECS200-513-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61-68-7 |
| Catalog No. | 2A-9011316 |
| Chinese Name | 甲灭酸 |
| Synonyms | Ponstyl; Pontal; Parkemed; Mefenacid; Mefenamate; EINECS 200-513-1; Lysalgo; MFCD00051721; Ponalar; Mefenamic acid; 2-[(2,3-Dimethylphenyl)amino]benzoic acid; Ponstel; N-(2,3-Xylyl)anthranilic acid; Ponstan |
| Molecular Formula | C15H15NO2 |
| Molecular Weight | 241.29 |
| Purity | 99.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 398.8±30.0 °C at 760 mmHg |
| Melting Point | 230 °C |
| Appearance | Light yellow solid |
| Storage Condition | Refrigerator |
| Application | Mefenamic acid is a non-steroidal anti-inflammatory agent and a competitive hCOX-1 and hCOX-2 inhibitor with IC50 values of 40 nM and 3 μM respectively. |
| EINECS | 200-513-1 |
| HTC | 2922499990 |
| PubChem ID | 24896815 |
| MDL Number | MFCD00051721 |
| SMILES | Cc1cccc(Nc2ccccc2C(O)=O)c1C |
| InChI | 1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18) |
| InChI Key | HYYBABOKPJLUIN-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12161501 |
| Hazard Symbols | Transport |
| MSDS | msds/11316_1_61_68_7.pdf |
| Bioactivity | Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Related Catalog Research Areas >> Inflammation/Immunology Target hCOX-1:40 nM (IC50) hCOX-2:3 μM (IC50) In Vitro Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1]. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid[2]. Cell Assay Powder forms of Mefenamic acid, indometacin, aspirin, and celecoxib are dissolved in 0.1% dimethyl sulfoxide (DMSO) to achieve a concentration of 100 μM of stock solution, which is sterilized by filtration through a 0.22-µm filter and then stored at 4°C. Different concentrations (100, 50, 25, 10, and 5 μM) of the drugs (Mefenamic acid, etc.) are prepared by serial dilutions with the FCS-free medium or the medium containing 10% FCS in sterile plastic centrifuge tubes[2]. References [1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 398.8±30.0 °C at 760 mmHg Melting Point 230 °C Molecular Formula C15H15NO2 Molecular Weight 241.285 Flash Point 195.0±24.6 °C Exact Mass 241.110275 PSA 49.33000 LogP 5.33 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.639 InChIKey HYYBABOKPJLUIN-UHFFFAOYSA-N SMILES Cc1cccc(Nc2ccccc2C(=O)O)c1C Storage condition Refrigerator |
| Use of | Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Properties Articles72 Name mefenamic acid Synonym More Synonyms Mefenamic acid Biological Activity Description Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Related Catalog Research Areas >> Inflammation/Immunology hCOX-1:40 nM (IC50) hCOX-2:3 μM (IC50) In Vitro Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1]. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid[2]. References [1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25. Chemical & Physical Properties Molecular Formula C15H15NO2 Exact Mass 241.110275 PSA 49.33000 Index of Refraction 1.639 InChIKey HYYBABOKPJLUIN-UHFFFAOYSA-N Storage condition Refrigerator |
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| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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