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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 2-(1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)-1-MORPHOLINOETHANONE
2-(1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)-1-MORPHOLINOETHANONE structure, CAS 2854-32-2

2-(1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)-1-MORPHOLINOETHANONE

CAS Number2854-32-2

Synonyms2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone; Indomethacin morpholinamide; Lopac-I-151; BML-190; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(morpholin-4-yl)ethanone; Ethanone (2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl); Tocris-1383; 2-Methyl-5-methoxy-3-indolyl-essigsaeure-amid; IMMA; Indomethacin morpholinylamide; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone

Molecular FormulaC23H23O4N2Cl1

Molecular Weight426.9

Purity96+%

Density1.3±0.1 g/cm3

Boiling Point586.7±50.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancesolid | off-white

EINECS0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-0113153 Purity: 96+%
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Quality Control of [ 2854-32-2 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2854-32-2
Catalog No.2A-0113153
Chinese Name2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮
Synonyms2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone; Indomethacin morpholinamide; Lopac-I-151; BML-190; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(morpholin-4-yl)ethanone; Ethanone (2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl); Tocris-1383; 2-Methyl-5-methoxy-3-indolyl-essigsaeure-amid; IMMA; Indomethacin morpholinylamide; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone
Molecular FormulaC23H23O4N2Cl1
Molecular Weight426.9
Purity96+
Density1.3±0.1 g/cm3
Boiling Point586.7±50.0 °C at 760 mmHg
Appearancesolid | off-white
Water SolubilityDMSO: >20mg/mL
Storage Condition2-8°C
ApplicationBML-190 (IMMA) is a ligand for CB2 receptors, with Ki of 435 nM and >2 μM for CB2 and CB1 receptors, respectively.
EINECS0
HTC2934999090
UN(IATA)0
MDL NumberMFCD01317813
SMILESCOc1ccc2c(c1)c(CC(=O)N1CCOCC1)c(C)n2C(=O)c1ccc(Cl)cc1
InChIInChI=1S/C23H23ClN2O4/c1-23(22(28)15-3-5-16(24)6-4-15)19(14-21(27)26-9-11-30-12-10-26)18-13-17(29-2)7-8-20(18)25-23/h3-8,13H,9-12,14H2,1-2H3
InChI KeyBJSDNVVWJYDOLK-UHFFFAOYSA-N
Use ofProperties Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone Synonym More Synonyms BML-190 Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Research Areas >> Cancer References [1]. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences ( [2]. Klegeris, Andis; Bissonnette, Christopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786. [3]. New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60. Chemical & Physical Properties Exact Mass 426.134644 PSA 60.77000 Appearance of Characters solid | off-white Index of Refraction 1.625 InChIKey BJSDNVVWJYDOLK-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Morpholine, 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl) acetyl)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C23-H23-Cl-N2-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T56 BNJ BVR DG& C1 GO1 D1V- AT6N DOTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,309,1975 Safety Information WGK Germany 3 HS Code 2934999090 Synthetic Route Total: 1 Page morpholine CAS#:110-91-8 Indometacin CAS#:53-86-1 CAS#:2854-32-2 Literature: Kalgutkar, Amit S.; Marnett, Alan B.; Crews, Brenda C.; Remmel, Rory P.; Marnett, Lawrence J. Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2860 - 2870 5-methoxy-2-met... CAS#:2882-15-7 CAS#:2854-32-2 Literature: Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268 4-Chlorobenzoyl... CAS#:122-01-0 CAS#:180002-77-1 CAS#:2854-32-2 Literature: Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268 Precursor & DownStream Precursor 4 CAS#:110-91-8 morpholine CAS#:53-86-1 Indometacin CAS#:2882-15-7 5-methoxy-2-met... CAS#:122-01-0 4-Chlorobenzoyl... DownStream 0
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SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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