CAS Number2437-29-8
SynonymsEINECS 219-441-7; 4,4'-bis-dimethylamino-tritylium,oxalate; Malachite Green,Oxalate; Basisgreen4; Malachite Green oxalate,certified; OXALATE; MFCD00011766; Malachite green oxalate; LIGHT GREEN N; SOLID GREEN O; malachite green,oxalate salt; Ethanedioate; BASIC GREEN; 4,4'-Bis-dimethylamino-tritylium,Oxalat; Carboxyformate; Malachite green
Molecular FormulaC52H54N4O12
Molecular Weight463.50
Purity98.00%
Melting Point144-150 °C
Appearancepowder or crystals
EINECS219-441-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2437-29-8 |
| Catalog No. | 2A-9011277 |
| Chinese Name | 孔雀石绿 |
| Synonyms | EINECS 219-441-7; 4,4'-bis-dimethylamino-tritylium,oxalate; Malachite Green,Oxalate; Basisgreen4; Malachite Green oxalate,certified; OXALATE; MFCD00011766; Malachite green oxalate; LIGHT GREEN N; SOLID GREEN O; malachite green,oxalate salt; Ethanedioate; BASIC GREEN; 4,4'-Bis-dimethylamino-tritylium,Oxalat; Carboxyformate; Malachite green |
| Molecular Formula | C52H54N4O12 |
| Molecular Weight | 463.50 |
| Purity | 98.00 |
| Melting Point | 144-150 °C |
| Appearance | powder or crystals |
| Water Solubility | 60 g/L (20 ºC) |
| Storage Condition | Place in a tight container, store in a cool, dry p |
| Packaging | III |
| Application | Malachite green oxalate is a triphenylmethane dye that can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, |
| EINECS | 219-441-7 |
| HTC | 32041300 |
| PubChem ID | 24897308 |
| SMILES | C[N+](C)=C1C=CC(C=C1)=C(C2=CC=C(N(C)C)C=C2)C3=CC=CC=C3.[O-]C(C(O)=O)=O |
| InChI | 1S/C23H25N2.C2H2O4/c1-24(2)21-14-10-19(11-15-21)23(18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4;3-1(4)2(5)6/h5-17H,1-4H3;(H,3,4)(H,5,6)/q+1;/p-1 |
| InChI Key | REZFCYOVFCJTDG-UHFFFAOYSA-M |
| Beilstein/REAXYS | 3644550 |
| NACRES Code | NA.47 |
| UNSPSC | 12171500 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11277_1_2437_29_8.pdf |
| Bioactivity | Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3]. Related Catalog Signaling Pathways >> NF-κB >> IKK Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Target IKBKE[3] References [1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87. Chemical & Physical Properties Melting Point 164°C (dec.) Molecular Formula C52H54N4O12 Molecular Weight 927.0 Exact Mass 927.0 PSA 241.96000 LogP 3.58460 InChIKey CNYGFPPAGUCRIC-UHFFFAOYSA-L SMILES CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccccc2)cc1.CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccccc2)cc1.O=C(O)C(=O)O.O=C([O-])C(=O)O.O=C([O-])C(=O)O Storage condition Store at RT. Water Solubility 60 g/L (20 ºC) |
| Use of | Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3]. Properties Articles35 Name Basic Green 4 Synonym More Synonyms Malachite green oxalate Biological Activity Description Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3]. Related Catalog Signaling Pathways >> NF-κB >> IKK Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87. Chemical & Physical Properties Molecular Formula C52H54N4O12 Exact Mass 927.0 PSA 241.96000 LogP 3.58460 InChIKey CNYGFPPAGUCRIC-UHFFFAOYSA-L Storage condition Store at RT. |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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