| Chemical & Physical Properties | |
|---|---|
| CAS Number | 17575-22-3 |
| Catalog No. | 2A-9011122 |
| Chinese Name | 毛花苷C |
| Synonyms | EINECS 241-546-1; lanatoside c; MFCD00079404 |
| Molecular Formula | C49H76O20 |
| Molecular Weight | 985.12 |
| Purity | ≥97 (TLC) |
| Density | 1.42g/cm3 |
| Melting Point | 272-274°C |
| Appearance | powder |
| Application | Lanatoside C is a cardiac glycoside that can be used to treat congestive heart failure and arrhythmias. Lanatoside C acts on HuH-7 cells and resists dengue virus infection, with an IC50 of 0.19 μM. |
| EINECS | 241-546-1 |
| PubChem ID | 24896307 |
| MDL Number | MFCD00869432 |
| SMILES | C[C@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(C)=O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)O[C@H]5CC[C@@]6(C)[C@H](CC[C@@H]7[C@@H]6C[C@@H](O)[C@]8(C)[C@H](CC[C@]78O)C9=CC(=O)OC9)C5 |
| InChI | 1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29-,30+,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1 |
| InChI Key | JAYAGJDXJIDEKI-PTGWOZRBSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352201 |
| Hazard Symbols | Transport |
| MSDS | msds/11122_1_17575_22_3.pdf |
| Bioactivity | Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Target:in vitro: Dose-dependent reduction in dengue viral RNA and viral proteins synthesis were also observed upon treatment with increasing concentrations of Lanatoside C. Time of addition study indicated that Lanatoside C inhibits the early processes of the dengue virus replication cycle. Furthermore, Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71. Lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses. [2] Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease Natural Products >> Steroids References [1]. Crommentuijn MH, et al. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2015 Dec 11. pii: S1574-7891(15)00226-4. [2]. Cheung YY, et al. Antiviral activity of lanatoside C against dengue virus infection. Antiviral Res. 2014 Nov;111:93-99. Chemical & Physical Properties Density 1.42g/cm3 Melting Point 272-274°C Molecular Formula C49H76O20 Molecular Weight 985.11600 Exact Mass 984.49300 PSA 288.28000 LogP 0.61310 Index of Refraction 1.608 InChIKey JAYAGJDXJIDEKI-PTGWOZRBSA-N SMILES CC(=O)OC1CC(OC2C(O)CC(OC3C(O)CC(OC4CCC5(C)C(CCC6C5CC(O)C5(C)C(C7=CC(=O)OC7)CCC65O)C4)OC3C)OC2C)OC(C)C1OC1OC(CO)C(O)C(O)C1O |
| Use of | Properties Articles27 Name Lanatoside C Synonym More Synonyms Lanatoside C Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease Natural Products >> Steroids References [1]. Crommentuijn MH, et al. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2015 Dec 11. pii: S1574-7891(15)00226-4. [2]. Cheung YY, et al. Antiviral activity of lanatoside C against dengue virus infection. Antiviral Res. 2014 Nov;111:93-99. Chemical & Physical Properties Molecular Formula C49H76O20 Exact Mass 984.49300 PSA 288.28000 LogP 0.61310 Index of Refraction 1.608 InChIKey JAYAGJDXJIDEKI-PTGWOZRBSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Lanatoside C) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Lanatoside C) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Lanatoside C) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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| Lanatoside A | 17575-20-1 | 2A-9011120 |
| Lanatoside B | 17575-21-2 | 2A-9011121 |
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| Laurcetium bromid | 1794-75-8 | 2A-9011130 |
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