CAS Number756525-91-4
Synonyms15-T-BUTYLOXYCARBONYLAMINO-4,7,10,13-TETRAOXA-PENTADECANOIC ACID; 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid; AmbotzPEG1920
Molecular FormulaC16H31NO8
Molecular Weight365.42
Purity96+%
Density1.1±0.1 g/cm3
Boiling Point504.5±50.0 °C at 760 mmHg
AppearanceLiquid;Colorless to Light yellow clear liquid
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 756525-91-4 |
| Catalog No. | 2A-1110635 |
| Chinese Name | 15-(Boc-氨基)-4,7,10,13-四氧杂十五烷酸 |
| Synonyms | 15-T-BUTYLOXYCARBONYLAMINO-4,7,10,13-TETRAOXA-PENTADECANOIC ACID; 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid; AmbotzPEG1920 |
| Molecular Formula | C16H31NO8 |
| Molecular Weight | 365.42 |
| Purity | 96+ |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 504.5±50.0 °C at 760 mmHg |
| Appearance | Liquid;Colorless to Light yellow clear liquid |
| Storage Condition | -20°C; store under inert gas; avoid light, moistur |
| Application | Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker used to synthesize PROTAC. Boc-NH-PEG4-CH2CH2COOH is also a degradable ADC linker, which is used in the synthesis of degradable antibody drug conjug |
| EINECS | 0 |
| HTC | 0 |
| UN(IATA) | 0 |
| MDL Number | MFCD07781254 |
| SMILES | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O |
| InChI Key | YEIYIPDFZMLJQH-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| Bioactivity | Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs). References [1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1. [2]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 504.5±50.0 °C at 760 mmHg Molecular Formula C16H31NO8 Molecular Weight 365.419 Flash Point 258.9±30.1 °C Exact Mass 365.204956 PSA 112.55000 LogP -0.14 Vapour Pressure 0.0±2.8 mmHg at 25°C Index of Refraction 1.466 InChIKey YEIYIPDFZMLJQH-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O |
| Use of | Properties Name 3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid Synonym More Synonyms Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs). References [1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1. [2]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1. Chemical & Physical Properties Molecular Formula C16H31NO8 Exact Mass 365.204956 PSA 112.55000 LogP -0.14 Index of Refraction 1.466 InChIKey YEIYIPDFZMLJQH-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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