CAS Number10436-25-6
Synonyms11-((tert-Butoxycarbonyl)amino)undecanoic acid; 11-[(2-methylpropan-2-yl)oxycarbonylamino]undecanoic acid; MFCD00076902
Molecular FormulaC16H31NO4
Molecular Weight301.42200
Purity96+%
Melting Point68 °C
AppearanceSolid;White to Almost white powder to crystal
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10436-25-6 |
| Catalog No. | 2A-0109935 |
| Chinese Name | 11-[(叔丁氧羰基)氨基]十一烷酸 |
| Synonyms | 11-((tert-Butoxycarbonyl)amino)undecanoic acid; 11-[(2-methylpropan-2-yl)oxycarbonylamino]undecanoic acid; MFCD00076902 |
| Molecular Formula | C16H31NO4 |
| Molecular Weight | 301.42200 |
| Purity | 96+ |
| Melting Point | 68 °C |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Seal in a cool, dry place. |
| Application | Boc-11-aminoundecanoic acid is a PROTAC linker based on Alkyl/ether structure, which can be used to prepare MS432 (HY-130602). |
| EINECS | 0 |
| HTC | 2924199090 |
| UN(IATA) | 0 |
| SMILES | CC(C)(C)OC(=O)NCCCCCCCCCCC(=O)O |
| InChI Key | HPTPZJBSQUULAV-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/109935_1_10436_25_6.pdf |
| Bioactivity | Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether In Vitro MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. References [1]. Wei J, et al.Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911. Chemical & Physical Properties Melting Point 68 °C Molecular Formula C16H31NO4 Molecular Weight 301.42200 Exact Mass 301.22500 PSA 75.63000 LogP 4.49750 InChIKey HPTPZJBSQUULAV-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCCCCCCCCCC(=O)O Storage condition 2-8°C |
| Use of | Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1]. Properties Name Boc-11-aminoundecanoic acid Synonym More Synonyms Boc-11-aminoundecanoic acid Biological Activity Description Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. References Chemical & Physical Properties Molecular Formula C16H31NO4 Exact Mass 301.22500 PSA 75.63000 LogP 4.49750 InChIKey HPTPZJBSQUULAV-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCCCCCCCCCC(=O)O |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Pharmaceutical Intermediates | ||
|---|---|---|
| 1-N-CBZ-4-HYDROXY-BETA-PROLINE | 886362-64-7 | 2A-0109516 |
| 1-PIPERAZINYL[3-(TRIFLUOROMETHYL)PHENYL]METHANONE | 179334-14-6 | 2A-0109704 |
| 1-TERT-BUTYL (2S,4R)-2-METHYL4-HYDROXYPIPERIDINE-1,2-DICARBOXYLATE | 181269-87-4 | 2A-0109782 |
| 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBALDEHYDE | 956716-93-1 | 2A-0109877 |
| 10-((TERT-BUTOXYCARBONYL)AMINO)DECANOIC ACID | 173606-50-3 | 2A-0109897 |
| 1H-PYRAZOLE-4-SULFONYL CHLORIDE | 438630-64-9 | 2A-0110111 |
| 1H-PYRROLO[2,3-B]PYRIDIN-6-OL | 55052-26-1 | 2A-0110157 |
| 1H-PYRROLO[2,3-B]PYRIDINE-2,3-DIONE | 5654-95-5 | 2A-0110159 |
| 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXAMIDE | 74420-16-9 | 2A-0110164 |
| 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE | 623163-58-6 | 2A-0110167 |
| Browse all Pharmaceutical Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS