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Iopromide structure, CAS 73334-07-3

Iopromide

CAS Number73334-07-3

Synonymsiopromide; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide; Ultravist; iopromida; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiod-5-[(methoxyacetyl)amino]-N-methylbenzol-1,3-dicarboxamid; iopromidum; EINECS 277-385-9; Ultravist 300; Ultravist 370; MFCD00867924

Molecular FormulaC18H24I3N3O8

Molecular Weight791.11

Purity99%

Density2.2±0.1 g/cm3

Boiling Point840.9±65.0 °C at 760 mmHg

Melting Pointbroad (160ºC transition)

Flash Point

AppearanceOff-white to white powder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9010986 Purity: 99%
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Quality Control of [ 73334-07-3 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number73334-07-3
Catalog No.2A-9010986
Chinese Name碘普罗胺
Synonymsiopromide; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide; Ultravist; iopromida; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiod-5-[(methoxyacetyl)amino]-N-methylbenzol-1,3-dicarboxamid; iopromidum; EINECS 277-385-9; Ultravist 300; Ultravist 370; MFCD00867924
Molecular FormulaC18H24I3N3O8
Molecular Weight791.11
Purity99
Density2.2±0.1 g/cm3
Boiling Point840.9±65.0 °C at 760 mmHg
Melting Pointbroad (160ºC transition)
AppearanceOff-white to white powder
Storage ConditionHygroscopic, -20?C Freezer, Under Inert Atmosphere
ApplicationIopromide is a water-soluble, low-penetration, non-ionic X-ray contrast agent for intravascular administration.
HTC2924299090
PubChem ID329750181
MDL NumberMFCD00867924
SMILESO=C(N(C)CC(O)CO)C1=C(I)C(NC(COC)=O)=C(I)C(C(NCC(CO)O)=O)=C1I
InChI1S/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29)
InChI KeyDGAIEPBNLOQYER-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/10986_1_73334_07_3.pdf
Use ofIopromide is a water-soluble, non-ionic, monomeric, low-osmolar, iodine-based contrast medium for intravascular administration. Properties Articles114 Name iopromide Synonym More Synonyms iopromide Biological Activity Description Iopromide is a water-soluble, non-ionic, monomeric, low-osmolar, iodine-based contrast medium for intravascular administration. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease In Vivo Contrast medium-induced nephropathy can be induced by tail intravenous administration of iopromide[1]. In randomized controlled trials, the global image quality and diagnostic quality with iobitridol does not differ from those with other low-osmolar contrast media (iohexol, iopromide, iopamidol, iomeprol and ioxaglate) or the iso-osmolar contrast medium iodixanol in adults or children undergoing radiographic imaging. Large post-marketing surveillance studies have confirmed that iobitridol produces good or excellent opacification and is an effective contrast agent in the vast majority of patients. Iobitridol is generally well tolerated and had a tolerability profile similar to that of other low-osmolar and iso-osmolar contrast media. Thus, iobitridol is an effective intravascular agent for contrast enhancement in diagnostic imaging[2]. References [1]. Jiang W, et al. Breviscapine attenuatted contrast medium-induced nephropathy via PKC/Akt/MAPK signalling in diabetic mice. Am J Transl Res. 2016 Feb 15;8(2):329-41. [2]. McCormack PL, et al. Iobitridol: a review of its use as a contrast medium in diagnostic imaging. Clin Drug Investig. 2013 Feb;33(2):155-66. Chemical & Physical Properties Molecular Formula C18H24I3N3O8 Exact Mass 790.869690 PSA 168.66000 LogP -2.95 Index of Refraction 1.710 InChIKey DGAIEPBNLOQYER-UHFFFAOYSA-N Storage condition Hygroscopic, -20?C Freezer, Under Inert Atmosphere Stability Hygroscopic Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((methoxyacetyl)amino )-N-methyl- 2,4,6-triiodo- CAS REGISTRY NUMBER : 73334-07-3 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C18-H24-I3-N3-O8 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 370,41,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AAJNDL AJNR, American Journal of Neuroradiology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1980- Volume(issue)/page/year: 4,350,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1275,1994 Safety Information Signal Word Warning Hazard Statements H410 Precautionary Statements P273-P501 Hazard Codes N Safety Phrases 60-61 RIDADR NONH for all modes of transport RTECS CZ2230000 HS Code 2924299090 Synthetic Route Total: 1 Page 5-methoxyacetyl... CAS#:1193076-40-2 CAS#:73334-07-3
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoProduct name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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