CAS Number26807-65-8
SynonymsNatrilix; Indamol; Bajaten; Indapamide; Veroxil; Natrix; N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline; N-(3-Sulfamyl-4-chlorobenzamido)-2-methylindoline; 4-Chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide; Arifon; 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide; Tertensif; MFCD00079375; Fludex; Tandix; Indaflex; Noranat; 1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline; EINECS 248-012-7; 4-Chlor-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzolcarboxamid; 1-(4-CHLORO-3-SULFAMOYLBENAZMIDO)-2-METHYL INDOLINE
Molecular FormulaC16H16ClN3O3S
Molecular Weight363.82
Purity99.5%
Density1.5±0.1 g/cm3
Melting Point160-162°C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26807-65-8 |
| Catalog No. | 2A-9010938 |
| Chinese Name | 吲达帕胺 |
| Synonyms | Natrilix; Indamol; Bajaten; Indapamide; Veroxil; Natrix; N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline; N-(3-Sulfamyl-4-chlorobenzamido)-2-methylindoline; 4-Chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide; Arifon; 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide; Tertensif; MFCD00079375; Fludex; Tandix; Indaflex; Noranat; 1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline; EINECS 248-012-7; 4-Chlor-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzolcarboxamid; 1-(4-CHLORO-3-SULFAMOYLBENAZMIDO)-2-METHYL INDOLINE |
| Molecular Formula | C16H16ClN3O3S |
| Molecular Weight | 363.82 |
| Purity | 99.5 |
| Density | 1.5±0.1 g/cm3 |
| Melting Point | 160-162°C |
| Appearance | powder |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Packaging | 1kg/foil bag |
| Application | Indapamide acts on potassium channels and is a non-thiazide sulfonamide diuretic. |
| HTC | 2935009090 |
| MDL Number | MFCD01667066 |
| SMILES | [S](=O)(=O)(N)c1c(ccc(c1)C(=O)N[n]2c3c(cc2C)cccc3)Cl |
| InChI | 1S/C16H14ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-9H,1H3,(H,19,21)(H2,18,22,23) |
| InChI Key | LWCDXWWLUHMMJI-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/10938_1_26807_65_8.pdf |
| Bioactivity | Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.Target: Potassium ChannelIndapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol. It is described as a thiazide-like diuretic. From WikipediaIndapamide evidently induces redistribution of the cardiac output, with enhanced muscle blood flow and reduced renal perfussion, and that AVP does not seem to be involved in blood pressure regulation in mild to moderate essential hypertension under basal conditions [1]. Indapamide SR provides an effective option for initial antihypertensive monotherapy and a basis for multidrug antihypertensive strategies[2] . Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Pedersen, E.B., H. Danielsen, and E.S. Spencer, Effect of indapamide on renal plasma flow, glomerular filtration rate and arginine vasopressin in plasma in essential hypertension. Eur J Clin Pharmacol, 1984. 26(5): p. 543-7. [2]. Robinson, D.M. and K. Wellington, Indapamide sustained release: a review of its use in the treatment of hypertension. Drugs, 2006. 66(2): p. 257-71. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Melting Point 160-162°C Molecular Formula C16H16ClN3O3S Molecular Weight 365.835 Exact Mass 365.060089 PSA 100.88000 LogP 2.10 Index of Refraction 1.694 InChIKey NDDAHWYSQHTHNT-UHFFFAOYSA-N SMILES CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1 |
| Use of | Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.Target: Potassium ChannelIndapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol. It is described as a thiazide-like diuretic. From WikipediaIndapamide evidently induces redistribution of the cardiac output, with enhanced muscle blood flow and reduced renal perfussion, and that AVP does not seem to be involved in blood pressure regulation in mild to moderate essential hypertension under basal conditions [1]. Indapamide SR provides an effective option for initial antihypertensive monotherapy and a basis for multidrug antihypertensive strategies[2] . Properties Articles53 Name indapamide Synonym More Synonyms Indapamide Biological Activity Description Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.Target: Potassium ChannelIndapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol. It is described as a thiazide-like diuretic. From WikipediaIndapamide evidently induces redistribution of the cardiac output, with enhanced muscle blood flow and reduced renal perfussion, and that AVP does not seem to be involved in blood pressure regulation in mild to moderate essential hypertension under basal conditions [1]. Indapamide SR provides an effective option for initial antihypertensive monotherapy and a basis for multidrug antihypertensive strategies[2] . Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Pedersen, E.B., H. Danielsen, and E.S. Spencer, Effect of indapamide on renal plasma flow, glomerular filtration rate and arginine vasopressin in plasma in essential hypertension. Eur J Clin Pharmacol, 1984. 26(5): p. 543-7. [2]. Robinson, D.M. and K. Wellington, Indapamide sustained release: a review of its use in the treatment of hypertension. Drugs, 2006. 66(2): p. 257-71. Chemical & Physical Properties Exact Mass 365.060089 PSA 100.88000 Index of Refraction 1.694 InChIKey NDDAHWYSQHTHNT-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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