CAS Number55-97-0
SynonymsN,N,N,N',N',N'-Hexamethyl-1,6-hexanediaminium dibromide; N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium dibromide; Hexamethonium bromide,N,N,N,N',N',N'-Hexamethylhexamethylenediammoniumdibromide; Hexamethonium bromide; MFCD00011787; 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide; Hexamethylenebis(trimethylammonium bromide); N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide; EINECS 200-249-7; 1,6-Hexanediaminium, N,N,N,N,N,N-hexamethyl-, bromide (1:2); Hexane-1,6-bis(trimethylammonium bromide); Hexamethonium (Bromide)
Molecular Formula(CH3)3N(Br)(CH2)6N(Br)(CH3)3
Molecular Weight362.19
Purity98%
Melting Point282-285 °C (dec.)
AppearanceWhite crystalline powder and agglomerates
EINECS200-249-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 55-97-0 |
| Catalog No. | 2A-9010841 |
| Chinese Name | 六甲溴铵 |
| Synonyms | N,N,N,N',N',N'-Hexamethyl-1,6-hexanediaminium dibromide; N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium dibromide; Hexamethonium bromide,N,N,N,N',N',N'-Hexamethylhexamethylenediammoniumdibromide; Hexamethonium bromide; MFCD00011787; 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide; Hexamethylenebis(trimethylammonium bromide); N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide; EINECS 200-249-7; 1,6-Hexanediaminium, N,N,N,N,N,N-hexamethyl-, bromide (1:2); Hexane-1,6-bis(trimethylammonium bromide); Hexamethonium (Bromide) |
| Molecular Formula | (CH3)3N(Br)(CH2)6N(Br)(CH3)3 |
| Molecular Weight | 362.19 |
| Purity | 98 |
| Melting Point | 282-285 °C (dec.) |
| Appearance | White crystalline powder and agglomerates |
| Water Solubility | Water solubility: soluble; soluble in: alcohol; in |
| Storage Condition | This product should be kept sealed and dry. |
| Application | Hexamethonium bromide is a non-depolarizing ganglion blocker and nAChR antagonist. |
| EINECS | 200-249-7 |
| PubChem ID | 24278459 |
| MDL Number | MFCD00011787 |
| SMILES | [Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C |
| InChI | 1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2 |
| InChI Key | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| Beilstein/REAXYS | 3715749 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10841_1_55_97_0.pdf |
| Bioactivity | Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Maneckjee, R. and J.D. Minna, Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ, 1994. 5(10): p. 1033-40. [2]. Sanchez-Fortun, S., F. Sanz, and M.V. Barahona, Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae. Arch Environ Contam Toxicol, 1996. 31(3): p. 391-8. [3]. Villablanca, A.C., Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol (1985), 1998. 84(6): p. 2089-98. Chemical & Physical Properties Melting Point ~285 °C (dec.) Molecular Formula C12H30Br2N2 Molecular Weight 362.188 Exact Mass 360.077545 InChIKey FAPSXSAPXXJTOU-UHFFFAOYSA-L SMILES C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-] Storage condition Desiccate at RT |
| Use of | Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3]. Properties Articles46 Name hexamethonium bromide Synonym More Synonyms Hexamethonium bromide Biological Activity Description Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Maneckjee, R. and J.D. Minna, Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ, 1994. 5(10): p. 1033-40. [2]. Sanchez-Fortun, S., F. Sanz, and M.V. Barahona, Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae. Arch Environ Contam Toxicol, 1996. 31(3): p. 391-8. [3]. Villablanca, A.C., Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol (1985), 1998. 84(6): p. 2089-98. Chemical & Physical Properties Molecular Formula C12H30Br2N2 Exact Mass 360.077545 InChIKey FAPSXSAPXXJTOU-UHFFFAOYSA-L SMILES C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-] Storage condition Desiccate at RT |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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