CAS Number467-55-0
Synonyms5ALPHA-SPIROSTAN-3BETA-OL-12-ONE; (25R)-5-Spirostan-3-ol-12-one; MFCD00067285; (22R,25R)-3β-Hydroxy-5α-spirostan-12-one; 12-Oxotigogenin; (3β,5α,25R)-3-Hydroxyspirostan-12-one; Hocogenin; Hecoginin; (25R)-3b-Hydroxy-5a-spirostan-12-one; Hecogenin; EINECS 207-392-4; 3-b-Hydroxy-5-a-spirostan-12-one; (3,5,25R)-3-Hydroxysiprostan-1; (3,5,25R)-3-Hydroxysiprostan-12-one; (3b,5a,25R)-3-Hydroxyspirostan-12-one
Molecular FormulaC27H42O4
Molecular Weight430.62
Purity≥90.0 (GC)%
Density1.2±0.1 g/cm3
Boiling Point548.9±50.0 °C at 760 mmHg
Melting Point268°C
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 467-55-0 |
| Catalog No. | 2A-9010830 |
| Chinese Name | 海柯皂苷元 |
| Synonyms | 5ALPHA-SPIROSTAN-3BETA-OL-12-ONE; (25R)-5-Spirostan-3-ol-12-one; MFCD00067285; (22R,25R)-3β-Hydroxy-5α-spirostan-12-one; 12-Oxotigogenin; (3β,5α,25R)-3-Hydroxyspirostan-12-one; Hocogenin; Hecoginin; (25R)-3b-Hydroxy-5a-spirostan-12-one; Hecogenin; EINECS 207-392-4; 3-b-Hydroxy-5-a-spirostan-12-one; (3,5,25R)-3-Hydroxysiprostan-1; (3,5,25R)-3-Hydroxysiprostan-12-one; (3b,5a,25R)-3-Hydroxyspirostan-12-one |
| Molecular Formula | C27H42O4 |
| Molecular Weight | 430.62 |
| Purity | ≥90.0 (GC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 548.9±50.0 °C at 760 mmHg |
| Melting Point | 268°C |
| Appearance | white solid |
| Storage Condition | Store in a sealed container in a ventilated and dr |
| Application | Hecogenin is a steroid saponin isolated from agave (Agave sisalana) and is a selective inhibitor of human UDP-glucuronyl glycosyltransferase. Hecogenin has a wide range of pharmacological activities, |
| MDL Number | MFCD00067285 |
| SMILES | [H]C1(C)CC[C@@]2(OC1)OC3CC4C5CC[C@@]6([H])CC(O)CCC6(C)C5CC(=O)C4(C)C3[C@@H]2C |
| InChI | 1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)12-21-19-6-5-17-11-18(28)8-9-25(17,3)20(19)13-23(29)26(21,24)4/h15-22,24,28H,5-14H2,1-4H3/t15-,16+,17+,18+,19-,20+,21+,22+,24+,25+,26-,27-/m1/s1 |
| InChI Key | QOLRLLFJMZLYQJ-LOBDNJQFSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10830_1_467_55_0.pdf |
| Bioactivity | Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Others >> Others Target Human UDP-glucuronosyltransferases[1] In Vivo Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1]. Animal Model: Male Swiss mice (20-30 g) with ethanol[1] Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg Administration: Oral administration; for 15 hours Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa. References [1]. Santos Cerqueira G, et al. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. Eur J Pharmacol. 2012 May 15;683(1-3):260-9. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 548.9±50.0 °C at 760 mmHg Melting Point 268°C Molecular Formula C27H42O4 Molecular Weight 430.620 Flash Point 177.8±23.6 °C Exact Mass 430.308319 PSA 55.76000 LogP 4.22 Vapour Pressure 0.0±3.3 mmHg at 25°C Index of Refraction 1.559 InChIKey QOLRLLFJMZLYQJ-LOBDNJQFSA-N SMILES CC1CCC2(OC1)OC1CC3C4CCC5CC(O)CCC5(C)C4CC(=O)C3(C)C1C2C |
| Use of | Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1]. Properties Name Hecogenin Synonym More Synonyms Hecogenin Biological Activity Description Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Others >> Others Human UDP-glucuronosyltransferases[1] References [1]. Santos Cerqueira G, et al. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. Eur J Pharmacol. 2012 May 15;683(1-3):260-9. Chemical & Physical Properties Molecular Formula C27H42O4 Exact Mass 430.308319 PSA 55.76000 Index of Refraction 1.559 InChIKey QOLRLLFJMZLYQJ-LOBDNJQFSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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