| Chemical & Physical Properties | |
|---|---|
| CAS Number | 100957-85-5 |
| Catalog No. | 2A-0107408 |
| Chinese Name | 1-苄基-3-(叔丁基)-1H-吡唑-5-羧酸 |
| Synonyms | 2-benzyl-5-tert-butyl-2H-pyrazole-3-carboxylic acid |
| Molecular Formula | C15H18O2N2 |
| Molecular Weight | 258.32 |
| Purity | 96+ |
| Density | 1.12g/cm3 |
| Boiling Point | 438.4ºC at 760 mmHg |
| Melting Point | 126ºC |
| Appearance | solid |
| Storage Condition | room temperature, inert gas |
| Application | SORT-PGRN interaction inhibitor 1 is a potent inhibitor of sortilin-progranulin interaction with IC50 of 2 μM. |
| EINECS | 0 |
| HTC | 2933199090 |
| UN(IATA) | 0 |
| MDL Number | MFCD02090479 |
| MSDS | msds/107408_1_100957_85_5.pdf |
| Bioactivity | SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease Target IC50: 2 μM (Sortilin-progranulin interaction)[1] In Vitro SORT-PGRN interaction inhibitor 1 (Compound 2) with sufficient potency and physicochemical properties to enable co-crystallization with sortilin[1]. References [1]. Shawn J Stachel, et al. Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. Chemical & Physical Properties Density 1.12g/cm3 Boiling Point 438.4ºC at 760 mmHg Melting Point 126ºC Molecular Formula C15H18N2O2 Molecular Weight 258.31600 Flash Point 218.9ºC Exact Mass 258.13700 PSA 55.12000 LogP 2.92710 Vapour Pressure 1.85E-08mmHg at 25°C Index of Refraction 1.568 |
| Use of | SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM[1]. Properties Name 2-benzyl-5-tert-butylpyrazole-3-carboxylic acid Synonym More Synonyms SORT-PGRN interaction inhibitor 1 Biological Activity Description SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease IC50: 2 μM (Sortilin-progranulin interaction)[1] In Vitro SORT-PGRN interaction inhibitor 1 (Compound 2) with sufficient potency and physicochemical properties to enable co-crystallization with sortilin[1]. References [1]. Shawn J Stachel, et al. Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. Chemical & Physical Properties Molecular Formula C15H18N2O2 Exact Mass 258.13700 PSA 55.12000 LogP 2.92710 Index of Refraction 1.568 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Heterocyclic Building Blocks | ||
|---|---|---|
| 1-BENZYL-2-(PERFLUOROPROPYL)-4,5-DIHYDRO-1H-IMIDAZOLE | 1069085-51-3 | 2A-0107388 |
| 1-BENZYL-2-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-IMIDAZOLE | 1069085-40-0 | 2A-0107389 |
| 1-BENZYL-2-[DIFLUORO(PHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE | 1069085-16-0 | 2A-0107390 |
| 1-BENZYL-3-(CHLOROMETHYL)-1H-INDAZOLE | 131427-22-0 | 2A-0107404 |
| 1-BENZYL-3-(CHLOROMETHYL)PIPERIDINE | 104778-58-7 | 2A-0107405 |
| 1-BENZYL-3-BUTYLPIPERAZINE | 175357-61-6 | 2A-0107416 |
| 1-BENZYL-3-HYDROXYPIPERIDINE-3-CARBONITRILE | 150018-99-8 | 2A-0107421 |
| 1-BENZYL-3-METHANESULFONYLOXYAZETIDINE | 67160-49-0 | 2A-0107422 |
| 1-BENZYL-3-METHYLPIPERAZINE-2,5-DIONE | 132871-09-1 | 2A-0107426 |
| 1-BENZYL-3-METHYLPYRROLIDINE-3-CARBONITRILE | 114273-05-6 | 2A-0107430 |
| Browse all Heterocyclic Building Blocks products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS