CAS Number56974-61-9
Synonymsbenzoic acid, 4-[[6-[(diaminomethylene)amino]-1-oxohexyl]oxy]-, ethyl ester, methanesulfonate (1:1); ethyl 4-({6-[(diaminomethylidene)amino]hexanoyl}oxy)benzoate methanesulfonate (1:1); Ethyl 4-[(6-carbamimidamidohexanoyl)oxy]benzoate methanesulfonate (1:1); Gabexate monomethanesulfonate; Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester, methanesulfonate (1:1); MFCD00210299; Ethyl 4-({6-[(diaminomethylene)amino]hexanoyl}oxy)benzoate methanesulfonate (1:1); Gabexate mesylate
Molecular FormulaC17H27N3O7S
Molecular Weight417.48
Purity≥97 (HPLC)%
Boiling Point508.6ºC at 760 mmHg
Melting Point91 °C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56974-61-9 |
| Catalog No. | 2A-9010670 |
| Chinese Name | 甲磺酸加贝酯 |
| Synonyms | benzoic acid, 4-[[6-[(diaminomethylene)amino]-1-oxohexyl]oxy]-, ethyl ester, methanesulfonate (1:1); ethyl 4-({6-[(diaminomethylidene)amino]hexanoyl}oxy)benzoate methanesulfonate (1:1); Ethyl 4-[(6-carbamimidamidohexanoyl)oxy]benzoate methanesulfonate (1:1); Gabexate monomethanesulfonate; Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester, methanesulfonate (1:1); MFCD00210299; Ethyl 4-({6-[(diaminomethylene)amino]hexanoyl}oxy)benzoate methanesulfonate (1:1); Gabexate mesylate |
| Molecular Formula | C17H27N3O7S |
| Molecular Weight | 417.48 |
| Purity | ≥97 (HPLC) |
| Boiling Point | 508.6ºC at 760 mmHg |
| Melting Point | 91 °C |
| Appearance | powder |
| Water Solubility | Water solubility: completely dissolved; easily sol |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | Gabexate mesylate is a non-antigenic trypsin-like serine protease inhibitor. |
| MDL Number | MFCD00210299 |
| SMILES | CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1 |
| InChI | 1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4) |
| InChI Key | DNTNDFLIKUKKOC-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10670_1_56974_61_9.pdf |
| Bioactivity | Gabexate Mesylate is a Factor X inhibitor; serine protease inhibitor .Target: Factor XGabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Values of the inhibition constant (K(i)) for gabexate mesylate binding to human and bovine tryptase were 3.4 x 10(-9) M and 1.8 x 10(-7) M (at pH 7.4 and 37.0 degrees ), respectively. Gabexate mesylate inhibited the fibrinogenolytic activity of human tryptase [1]. Gabexate Mesylate decreased the TNFalpha production of LPS-stimulated monocytes as shown by the inhibition of mRNA expression and increased the IL-10 production of LPS-stimulated monocytes. Gabexate Mesylate also suppressed the NFkappaB activity of LPS-stimulated monocytes. Inhibitory effect of Gabexate Mesylate on the TNFalpha production of activated human monocytes is mediated by the suppression of NFkappaB activation [2]. Gabexate mesylate inhibits competitively constitutive and inducible NO synthase (cNOS and iNOS, respectively), with Kivalues of 1.0×10?4M and 5.0×10?3M, respectively, at pH 7.4 and 37.0°C. gabexate mesylate increases iNOS mRNA expression in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ. Gabexate mesylate inhibits dose-dependently nitrite production (i.e. NO release) in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ [3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Inflammation/Immunology References [1]. Erba, F., et al., Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol, 2001. 61(3): p. 271-6. [2]. Aosasa, S., et al., Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock, 2001. 15(2): p. 101-5. [3]. Colasanti, M., et al., Effect of gabexate mesylate (FOY), a drug for serine proteinase-mediated diseases, on the nitric oxide pathway. Biochem Biophys Res Commun, 1998. 246(2): p. 453-6. Chemical & Physical Properties Boiling Point 508.6ºC at 760 mmHg Melting Point 91 °C Molecular Formula C17H27N3O7S Molecular Weight 417.477 Flash Point 261.4ºC Exact Mass 417.156982 PSA 177.25000 LogP 3.58790 Storage condition -20°C |
| Use of | Properties Articles30 Name Gabexate Mesylate Synonym More Synonyms Gabexate mesylate Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Inflammation/Immunology References [1]. Erba, F., et al., Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol, 2001. 61(3): p. 271-6. [2]. Aosasa, S., et al., Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock, 2001. 15(2): p. 101-5. [3]. Colasanti, M., et al., Effect of gabexate mesylate (FOY), a drug for serine proteinase-mediated diseases, on the nitric oxide pathway. Biochem Biophys Res Commun, 1998. 246(2): p. 453-6. Chemical & Physical Properties Molecular Formula C17H27N3O7S Exact Mass 417.156982 PSA 177.25000 LogP 3.58790 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Furomine | 142996-66-5 | 2A-9010662 |
| Fursalan | 15686-77-8 | 2A-9010664 |
| Fursultiamine | 804-30-8 | 2A-9010665 |
| Fusidic acid | 6990-06-3 | 2A-9010666 |
| Gabexate | 39492-01-8 | 2A-9010669 |
| Gadobutrol | 138071-82-6 | 2A-9010671 |
| Gadodiamide | 131410-48-5 | 2A-9010672 |
| Gadoteric acid | 72573-82-1 | 2A-9010675 |
| Gadoteridol | 120066-54-8 | 2A-9010676 |
| Gadoversetamide | 131069-91-5 | 2A-9010677 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS