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Furazolidone structure, CAS 67-45-8

Furazolidone

CAS Number67-45-8

SynonymsFurall; Bifuron; MFCD00010550; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone; 3-{(E)-[(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone; Furidon; Furazolidone; 3-{[(E)-(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; Neftin; nf-180; Furazon; Furazol; Furaxon; Furox; 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone; EINECS 200-653-3

Molecular FormulaC8H7N3O5

Molecular Weight225.16

Purity98%

Density1.7±0.1 g/cm3

Boiling Point353.4±52.0 °C at 760 mmHg

Melting Point256-256 °C

Flash Point

Appearancepowder

EINECS200-653-3

MSDSChineseEnglish

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Cat. No.: 2A-9010656 Purity: 98%
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Quality Control of [ 67-45-8 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number67-45-8
Catalog No.2A-9010656
Chinese Name呋喃唑酮
SynonymsFurall; Bifuron; MFCD00010550; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone; 3-{(E)-[(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone; Furidon; Furazolidone; 3-{[(E)-(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; Neftin; nf-180; Furazon; Furazol; Furaxon; Furox; 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone; EINECS 200-653-3
Molecular FormulaC8H7N3O5
Molecular Weight225.16
Purity98
Density1.7±0.1 g/cm3
Boiling Point353.4±52.0 °C at 760 mmHg
Melting Point256-256 °C
Appearancepowder
Water Solubilityformic acid: soluble50mg/mL
Storage ConditionThis product should be sealed and stored in a cool
ApplicationFurazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. It inhibits AML1-ETO transformed cells with an IC50 of 12.7 μM.
EINECS200-653-3
HTC2934992000
PubChem ID24894997
MDL NumberMFCD00010550
SMILES[O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1
InChI1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
InChI KeyPLHJDBGFXBMTGZ-WEVVVXLNSA-N
Beilstein/REAXYS8317414
NACRES CodeNA.85
UNSPSC51102829
Hazard SymbolsTransport
MSDSmsds/10656_1_67_45_8.pdf
BioactivityFurazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Jiang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8(8):e72335. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 353.4±52.0 °C at 760 mmHg Melting Point 254-256ºC (dec.) Molecular Formula C8H7N3O5 Molecular Weight 225.158 Flash Point 167.5±30.7 °C Exact Mass 225.038574 PSA 100.86000 LogP -0.49 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.670 InChIKey PLHJDBGFXBMTGZ-UITAMQMPSA-N SMILES O=C1OCCN1N=Cc1ccc([N+](=O)[O-])o1 Storage condition 0-6°C Water Solubility formic acid: soluble50mg/mL
Use ofFurazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines. Properties Articles52 Name furazolidone Synonym More Synonyms Furazolidone Biological Activity Description Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Jiang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8(8):e72335. Chemical & Physical Properties Molecular Formula C8H7N3O5 Exact Mass 225.038574 PSA 100.86000 LogP -0.49 Index of Refraction 1.670 InChIKey PLHJDBGFXBMTGZ-UITAMQMPSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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