CAS Number63585-09-1
SynonymsPhosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt (1:3); Trisodium dioxidophosphinecarboxylate oxide; Foscanet sodium; Triapten; Foscarnet sodium; phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt; foscarnet sodim; MFCD00013973; trisodium dioxidophosphanecarboxylate oxide; SODIUM FOSCARNET; Phenytion Sodium; Foscavir; trisodium phosphonoformate; FOSCARNET TRISODIUM SALT; phosphonoformate sodium salt
Molecular FormulaCNa3O5P
Molecular Weight300.04
Purity99%
Boiling Point270-272°C
Melting Point62-65 °C(lit.)
AppearanceWhite or almost white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 63585-09-1 |
| Catalog No. | 2A-9010613 |
| Chinese Name | 膦甲酸钠 |
| Synonyms | Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt (1:3); Trisodium dioxidophosphinecarboxylate oxide; Foscanet sodium; Triapten; Foscarnet sodium; phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt; foscarnet sodim; MFCD00013973; trisodium dioxidophosphanecarboxylate oxide; SODIUM FOSCARNET; Phenytion Sodium; Foscavir; trisodium phosphonoformate; FOSCARNET TRISODIUM SALT; phosphonoformate sodium salt |
| Molecular Formula | CNa3O5P |
| Molecular Weight | 300.04 |
| Purity | 99 |
| Boiling Point | 270-272°C |
| Melting Point | 62-65 °C(lit.) |
| Appearance | White or almost white crystalline powder |
| Storage Condition | -20℃ |
| Packaging | II |
| Application | Foscarnet sodium (Trisodium phosphonoformate) is an inhibitor of viral DNA polymerase activity that reversibly inhibits viral replication. Foscarnet sodium is an antiherpesviral drug with potential fo |
| HTC | 2942000000 |
| SMILES | [Na+].[Na+].[Na+].[P](=O)([O-])([O-])C(=O)[O-].O.O.O.O.O.O |
| InChI | 1S/CH3O5P.3Na.6H2O/c2-1(3)7(4,5)6;;;;;;;;;/h(H,2,3)(H2,4,5,6);;;;6*1H2/q;3*+1;;;;;;/p-3 |
| InChI Key | ILRVASBWNRYBFD-UHFFFAOYSA-K |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10613_1_63585_09_1.pdf |
| Use of | Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3]. Properties Name trisodium phosphonoformate Synonym More Synonyms Foscarnet sodium Biological Activity Description Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3]. Related Catalog Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis In Vitro Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2]. References [1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24. Chemical & Physical Properties Molecular Formula CNa3O5P Exact Mass 191.917648 PSA 113.13000 InChIKey DFHAXXVZCFXGOQ-UHFFFAOYSA-K SMILES O=C([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+] Storage condition -20℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt CAS REGISTRY NUMBER : 63585-09-1 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C-O5-P.3Na MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,216,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4215113 Safety Information Hazard Codes Xi Safety Phrases S26-S36 WGK Germany 3 Packaging Group II HS Code 2942000000 Synthetic Route Total: 1 Page phenyl [ethoxy-... CAS#:72304-84-8 Foscarnet sodium CAS#:63585-09-1 [hydroxy-(4-met... CAS#:74270-25-0 Literature: Noren; Helgstrand; Johansson; Misiorny; Stening Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 264 - 270 mono-(trimethyl... CAS#:91076-68-5 Hexamethyldisilazane CAS#:999-97-3 Foscarnet sodium CAS#:63585-09-1 Precursor & DownStream Precursor 3 CAS#:72304-84-8 phenyl [ethoxy-... CAS#:91076-68-5 mono-(trimethyl... CAS#:999-97-3 Hexamethyldisilazane DownStream 1 CAS#:1795-31-9 Tris(trimethyls... |
| Transport Info | Product name: Sodium foscarnet |
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