| Chemical & Physical Properties | |
|---|---|
| CAS Number | 168986-60-5 |
| Catalog No. | 2A-0105395 |
| Chinese Name | RS 67333 盐酸盐 |
| Synonyms | 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride |
| Molecular Formula | C19H30Cl2N2O2 |
| Molecular Weight | 389.36 |
| Purity | ≥98 (HPLC) |
| Boiling Point | 502.3ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in the guinea pig striatum. RS 67333 hydrochloride exhibits lower affinity at several other r |
| EINECS | 0 |
| HTC | 2933399090 |
| UN(IATA) | 0 |
| MDL Number | MFCD00938576 |
| SMILES | O=C(C1=CC(Cl)=C(N)C=C1OC)CCC2CCN(CCCC)CC2.[H]Cl |
| InChI | 1S/C19H29ClN2O2.ClH/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2;/h12-14H,3-11,21H2,1-2H3;1H |
| InChI Key | XVBGLZNYWUUAFF-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/105395_1_168986_60_5.pdf |
| Use of | Properties Name 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one,hydrochloride RS 67333 hydrochloride Biological Activity Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor 5-HT4 Receptor:8.7 (pKi) In Vitro RS 67333 hydrochloride does exhibit affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT[1]. References [1]. R M Eglen, et al. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br J Pharmacol. 1995 Aug;115(8):1387-92. Chemical & Physical Properties Exact Mass 388.16800 PSA 55.56000 LogP 5.72690 InChIKey XVBGLZNYWUUAFF-UHFFFAOYSA-N Safety Information HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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