CAS Number79660-72-3
SynonymsFleroxacin; MEGALONE; Megalocin; AM-833; Quinodis; 3-quinolinecarboxylicacid,1,4-dihydro-6,8-difluoro-1-(2-fluoroethyl)-7-(4-met; hyl-1-piperazinyl)-4-oxo; MFCD00864880; 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; RO-23-6240
Molecular FormulaC17H18F3N3O3
Molecular Weight369.34
Purity98%
Density1.4±0.1 g/cm3
Boiling Point535.3±50.0 °C at 760 mmHg
Melting Point264-266°C
Appearancewhite needle crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 79660-72-3 |
| Catalog No. | 2A-9010524 |
| Chinese Name | 氟罗沙星 |
| Synonyms | Fleroxacin; MEGALONE; Megalocin; AM-833; Quinodis; 3-quinolinecarboxylicacid,1,4-dihydro-6,8-difluoro-1-(2-fluoroethyl)-7-(4-met; hyl-1-piperazinyl)-4-oxo; MFCD00864880; 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; RO-23-6240 |
| Molecular Formula | C17H18F3N3O3 |
| Molecular Weight | 369.34 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 535.3±50.0 °C at 760 mmHg |
| Melting Point | 264-266°C |
| Appearance | white needle crystal |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Fleroxacin is a broad-spectrum fluoroquinolone antibiotic. |
| HTC | 2933990090 |
| MDL Number | C17H18F3N3O3 |
| SMILES | CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(CCF)c3c2F)CC1 |
| InChI | InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26) |
| InChI Key | XBJBPGROQZJDOJ-UHFFFAOYSA-N |
| MSDS | msds/10524_1_79660_72_3.pdf |
| Bioactivity | Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone.Target: AntibacterialFleroxacin (Ro 23-6240; AM-833) is a new trifluorinated quinolone exhibiting high activity against a broad spectrum of gram-negative and gram-positive bacteria. Fleroxacin is characterized pharmacokinetically by a long elimination half-life (9 to 10 h) and high concentrations in plasma (e.g., maximum concentration of 2.3 micrograms/ml after an oral dose of 200 mg) [1]. Fleroxacin is effective against Haemophilus ducreyi in vitro. Fleroxacin, 200 or 400 mg as a single oral dose, is efficacious therapy for microbiologically proven chancroid in patients who do not have concurrent HIV-1 infection. Among HIV-1-infected men, a single dose of 200 or 400 mg of fleroxacin is inadequate therapy for chancroid [2, 3]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Weidekamm, E., et al., Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans. Antimicrob Agents Chemother, 1987. 31(12): p. 1909-14. [2]. MacDonald, K.S., et al., Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Agents Chemother, 1989. 33(5): p. 612-4. [3]. Rubinstein, E., History of quinolones and their side effects. Chemotherapy, 2001. 47 Suppl 3: p. 3-8; discussion 44-8. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 535.3±50.0 °C at 760 mmHg Melting Point 264-266°C Molecular Formula C17H18F3N3O3 Molecular Weight 369.338 Flash Point 277.6±30.1 °C Exact Mass 369.130035 PSA 65.78000 LogP 1.72 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.568 InChIKey XBJBPGROQZJDOJ-UHFFFAOYSA-N SMILES CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(CCF)c3c2F)CC1 Storage condition 2-8°C |
| Use of | Properties Articles41 Name Fleroxacin Synonym More Synonyms Fleroxacin Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Weidekamm, E., et al., Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans. Antimicrob Agents Chemother, 1987. 31(12): p. 1909-14. [2]. MacDonald, K.S., et al., Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Agents Chemother, 1989. 33(5): p. 612-4. [3]. Rubinstein, E., History of quinolones and their side effects. Chemotherapy, 2001. 47 Suppl 3: p. 3-8; discussion 44-8. Chemical & Physical Properties Molecular Formula C17H18F3N3O3 Exact Mass 369.130035 PSA 65.78000 Index of Refraction 1.568 InChIKey XBJBPGROQZJDOJ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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