CAS Number83799-24-0
Synonyms4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetic acid; Fexofenadine-D5; Fexafenadine; 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)phenyl)-2-methylpropionic acid; CARBOXYTERFENADINE; Fexofenadine; Terfenadine acid; TERFENADINECARBOXYLATE; Telfast; MFCD00871892; 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid; 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid; Fexofenadinebase
Molecular FormulaC32H39O4N1
Molecular Weight501.67
Purity98%
Density1.2±0.1 g/cm3
Boiling Point697.3±55.0 °C at 760 mmHg
Melting Point218-220ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 83799-24-0 |
| Catalog No. | 2A-9010510 |
| Chinese Name | 非索芬那定 |
| Synonyms | 4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetic acid; Fexofenadine-D5; Fexafenadine; 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)phenyl)-2-methylpropionic acid; CARBOXYTERFENADINE; Fexofenadine; Terfenadine acid; TERFENADINECARBOXYLATE; Telfast; MFCD00871892; 2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid; 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid; Fexofenadinebase |
| Molecular Formula | C32H39O4N1 |
| Molecular Weight | 501.67 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 697.3±55.0 °C at 760 mmHg |
| Melting Point | 218-220ºC |
| Storage Condition | -20°C Freezer |
| Application | Fexofenadine (MDL-16455) is an orally active and non-stimulant H1 receptor antagonist. Fexofenadine can be used in research on allergic rhinitis and chronic idiopathic urticaria[1][2][3]. |
| HTC | 2933399090 |
| MDL Number | MFCD00871892 |
| SMILES | CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 |
| InChI | InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36) |
| InChI Key | RWTNPBWLLIMQHL-UHFFFAOYSA-N |
| MSDS | msds/10510_1_83799_24_0.pdf |
| Use of | Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3]. Properties Name fexofenadine Synonym More Synonyms Fexofenadine Biological Activity Description Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor In Vitro Fexofenadine (1-100 µM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner[2]. Fexofenadine (1-100 µM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK[2]. Western Blot Analysis[2] Cell Line: Nasal fibroblasts Concentration: 100 μM Incubation Time: 1 hour Result: Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway. Chemical & Physical Properties Molecular Formula C32H39NO4 Exact Mass 501.287903 PSA 81.00000 Index of Refraction 1.597 InChIKey RWTNPBWLLIMQHL-UHFFFAOYSA-N Safety Information HS Code 2933399090 Synthetic Route Fexofenadinone 76811-98-8 Fexofenadine 83799-24-0 Methyl 2-(4-(4-... 154477-55-1 Fexofenadine 83799-24-0 Literature: Journal of Organic Chemistry, , vol. 59, # 9 p. 2620 - 2622 Azacyclonol Fexofenadine 83799-24-0 Literature: Synthetic Communications, , vol. 26, # 24 p. 4699 - 4710 Precursor & DownStream Precursor 6 CAS#:76811-98-8 Fexofenadinone CAS#:154477-55-1 Methyl 2-(4-(4-... CAS#:115-46-8 Azacyclonol CAS#:50679-08-8 Terfenadine DownStream 1 CAS#:138452-21-8 Fexofenadine |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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