CAS Number67227-57-0
SynonymsEINECS 266-612-7; Fenoldopam monomethanesulfonate; MFCD04112986; 6-Chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepinium methanesulphonate; Corlopam; Fenoldopam methanesulfonate; 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate; 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol; Fenoldopam mesylate; 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine methanesulfonate; 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate; CORLOPAM MESYLATE; Fenoldopam (mesylate)
Molecular FormulaC17H20ClNO6S
Molecular Weight401.86
Purity≥98 (HPLC)%
Density1.38g/cm3
Boiling Point522.6ºC at 760 mmHg
Melting Point271 °C (lit.)
Appearancepowder
EINECS266-612-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67227-57-0 |
| Catalog No. | 2A-9010480 |
| Chinese Name | 6-氯-2,3,4,5-四氢-1-(4-羟苯基)-1H-3-苯并氮杂卓-7,8-二醇甲磺酸盐 |
| Synonyms | EINECS 266-612-7; Fenoldopam monomethanesulfonate; MFCD04112986; 6-Chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepinium methanesulphonate; Corlopam; Fenoldopam methanesulfonate; 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate; 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol; Fenoldopam mesylate; 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine methanesulfonate; 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate; CORLOPAM MESYLATE; Fenoldopam (mesylate) |
| Molecular Formula | C17H20ClNO6S |
| Molecular Weight | 401.86 |
| Purity | ≥98 (HPLC) |
| Density | 1.38g/cm3 |
| Boiling Point | 522.6ºC at 760 mmHg |
| Melting Point | 271 °C (lit.) |
| Appearance | powder |
| Storage Condition | room temp |
| Application | Fenoldopam (SKF 82526) mesylate is a selective agonist of dopamine receptor D1. |
| EINECS | 266-612-7 |
| PubChem ID | 329825223 |
| MDL Number | MFCD04112986 |
| SMILES | CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23 |
| InChI | 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4) |
| InChI Key | CVKUMNRCIJMVAR-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10480_1_67227_57_0.pdf |
| Bioactivity | Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 ± 7.75 nM vs. 1.65 ± 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 ± 2.95 pmol/mg of protein vs. 35.6 ± 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Cardiovascular Disease References [1]. Grenader, A. and D.P. Healy, Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther, 1991. 258(1): p. 193-8. [2]. Nichols, A.J., R.R. Ruffolo, Jr., and D.P. Brooks, The pharmacology of fenoldopam. Am J Hypertens, 1990. 3(6 Pt 2): p. 116S-119S. Chemical & Physical Properties Density 1.38g/cm3 Boiling Point 522.6ºC at 760 mmHg Molecular Formula C17H20ClNO6S Molecular Weight 401.86 Flash Point 269.9ºC PSA 104.24000 LogP 3.77680 InChIKey CVKUMNRCIJMVAR-UHFFFAOYSA-N SMILES CS(=O)(=O)O.Oc1ccc(C2CNCCc3c2cc(O)c(O)c3Cl)cc1 Storage condition room temp |
| Use of | Properties Articles33 Name 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,methanesulfonic acid Synonym More Synonyms Fenoldopam (mesylate) Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Cardiovascular Disease References [2]. Nichols, A.J., R.R. Ruffolo, Jr., and D.P. Brooks, The pharmacology of fenoldopam. Am J Hypertens, 1990. 3(6 Pt 2): p. 116S-119S. Chemical & Physical Properties PSA 104.24000 LogP 3.77680 InChIKey CVKUMNRCIJMVAR-UHFFFAOYSA-N Storage condition room temp |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Plastic & Specialty Additives | ||
|---|---|---|
| Dopastin | 37134-80-8 | 2A-9010229 |
| Dopexamine | 86197-47-9 | 2A-9010230 |
| Dopropidil | 79700-61-1 | 2A-9010231 |
| Droxidopa | 23651-95-8 | 2A-9010263 |
| Eletriptan | 143322-58-1 | 2A-9010296 |
| Gadopenamide | 117827-80-2 | 2A-9010673 |
| Gadopentetic acid | 80529-93-7 | 2A-9010674 |
| Glycerol tripalmitate | 555-44-2 | 2A-9010767 |
| Indoprofen | 31842-01-0 | 2A-9010947 |
| Methamidophos | 10265-92-6 | 2A-9011371 |
| Browse all Plastic & Specialty Additives products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS