CAS Number25451-15-4
SynonymsFelbatol; 3-propanediol dicarbamate; EINECS 247-001-4; Felbamatum; Felbamato; 1,3-Propanediol,2-phenyl-,dicarbamate; 1,3-bis-carbamoyloxy-2-phenyl-propane; 1,3-Bis-carbamoyloxy-2-phenyl-propan; MFCD00865296; 2-Phenyl-1,3-propanediyl dicarbamate; felbamate; Felbamyl; (3-carbamoyloxy-2-phenylpropyl) carbamate; Carbamic acid,2-phenyltrimethylene ester; 1,3-Propanediol, 2-phenyl-, dicarbamate; Taloxa; 2-Phenylpropane-1,3-diyl dicarbamate; 2-phenyl-1,3-propanediol dicarbamate
Molecular FormulaC11H14N2O4
Molecular Weight238.24
Purity97%
Density1.3±0.1 g/cm3
Boiling Point511.9±50.0 °C at 760 mmHg
Melting Point148-1500C
AppearanceWhite crystalline powder, melting point 151-152℃
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 25451-15-4 |
| Catalog No. | 2A-9010456 |
| Chinese Name | 非氨酯 |
| Synonyms | Felbatol; 3-propanediol dicarbamate; EINECS 247-001-4; Felbamatum; Felbamato; 1,3-Propanediol,2-phenyl-,dicarbamate; 1,3-bis-carbamoyloxy-2-phenyl-propane; 1,3-Bis-carbamoyloxy-2-phenyl-propan; MFCD00865296; 2-Phenyl-1,3-propanediyl dicarbamate; felbamate; Felbamyl; (3-carbamoyloxy-2-phenylpropyl) carbamate; Carbamic acid,2-phenyltrimethylene ester; 1,3-Propanediol, 2-phenyl-, dicarbamate; Taloxa; 2-Phenylpropane-1,3-diyl dicarbamate; 2-phenyl-1,3-propanediol dicarbamate |
| Molecular Formula | C11H14N2O4 |
| Molecular Weight | 238.24 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 511.9±50.0 °C at 760 mmHg |
| Melting Point | 148-1500C |
| Appearance | White crystalline powder, melting point 151-152℃ |
| Water Solubility | alcohol: soluble |
| Storage Condition | Store at RT |
| Application | Felbamate (FBM) is a non-sedating antispasmodic agent whose activity is related to NMDA receptors. |
| HTC | 2924299090 |
| PubChem ID | 329749831 |
| MDL Number | MFCD00865296 |
| SMILES | NC(=O)OCC(COC(N)=O)c1ccccc1 |
| InChI | 1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15) |
| InChI Key | WKGXYQFOCVYPAC-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10456_1_25451_15_4.pdf |
| Use of | Felbamate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .Target: NMDA ReceptorFelbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy.Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain. Properties Articles46 Name felbamate Synonym More Synonyms felbamate Biological Activity Description Felbamate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .Target: NMDA ReceptorFelbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy.Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Kuo CC, et al. Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Mol Pharmacol. 2004 Feb;65(2):370-80. [2]. Harty TP, et al. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39(1):47-55. Chemical & Physical Properties Molecular Formula C11H14N2O4 Exact Mass 238.095352 PSA 104.64000 Index of Refraction 1.559 InChIKey WKGXYQFOCVYPAC-UHFFFAOYSA-N Storage condition Store at RT Water Solubility alcohol: soluble Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,3-Propanediol, 2-phenyl-, dicarbamate CAS REGISTRY NUMBER : 25451-15-4 BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H14-N2-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : ZVO1YR&1OVZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Behavioral - sleep REFERENCE : PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1985- Volume(issue)/page/year: 11,369,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Gastrointestinal - other changes Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : PHPYDQ Pharmacotherapy (Carlisle, MA). (Pharmacotherapy Pub., Inc., 112 School St., Carlisle, MA 01741) V.1- 1981- Volume(issue)/page/year: 15,260,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,462,1969 Safety Information GHS02, GHS06, GHS08 Signal Word Danger Hazard Statements H225-H301 + H311 + H331-H370 Precautionary Statements P210-P260-P280-P301 + P310-P311 Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter RIDADR UN1230 - class 3 - PG 2 - Methanol WGK Germany 2 RTECS TZ1070000 HS Code 2924299090 Synthetic Route 2-Phenyl-1,3-pr... CAS#:1570-95-2 Sodium cyanate CAS#:917-61-3 CAS#:25451-15-4 2-Fluoro-2-phen... CAS#:211506-14-8 CAS#:25451-15-4 Hydroxy-2-pheny... CAS#:25451-53-0 N,N-Carbonyldii... CAS#:530-62-1 CAS#:25451-15-4 Literature: Chemical Research in Toxicology, , vol. 10, # 4 p. 457 - 462 Precursor & DownStream Precursor 7 CAS#:1570-95-2 2-Phenyl-1,3-pr... CAS#:917-61-3 Sodium cyanate CAS#:25451-53-0 Hydroxy-2-pheny... CAS#:530-62-1 N,N-Carbonyldii... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Fasidotril | 135038-57-2 | 2A-9010450 |
| Fasoracetam | 110958-19-5 | 2A-9010451 |
| Fasudil | 103745-39-7 | 2A-9010452 |
| Fasudil hydrochloride | 105628-07-7 | 2A-9010453 |
| Febantel | 58306-30-2 | 2A-9010454 |
| Felvizumab | 167747-20-8 | 2A-9010458 |
| Felypressin | 56-59-7 | 2A-9010459 |
| Fenabutene | 5984-83-8 | 2A-9010460 |
| Fenacetinol | 4665-04-7 | 2A-9010461 |
| Fenaminosulf | 140-56-7 | 2A-9010462 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS