CAS Number536-33-4
Synonyms2-ethyl-4-thiopyridylamide; 2-ethyl-4-thiocarbamoylpyridine; EINECS 208-628-9; Ethionamide; 2-Ethyl-4-pyridinecarbothioamide; Etionamid; 2-Ethyl-4-pyridinecarbothioamide,Ethionamide; Etioniamid; Trecator; Ethyonomide; Thioamide; Ethioniamide; Ethinamide; Ethylisothiamide; 2-Ethylpyridine-4-carbothioamide; 2-ethyl-4-thiocarbamoyl-4-pyridine; MFCD00057361; Trecator-SC; 2-Ethylthioisonicotinamide
Molecular FormulaC8H10N2S
Molecular Weight166.24
Purity≥98.0%
Density1.17 g/cm3
Boiling Point167 °C / 1mmHg
Melting Point164 °C
Appearancepowder
EINECS208-628-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 536-33-4 |
| Catalog No. | 2A-9010397 |
| Chinese Name | 乙硫异酰胺 |
| Synonyms | 2-ethyl-4-thiopyridylamide; 2-ethyl-4-thiocarbamoylpyridine; EINECS 208-628-9; Ethionamide; 2-Ethyl-4-pyridinecarbothioamide; Etionamid; 2-Ethyl-4-pyridinecarbothioamide,Ethionamide; Etioniamid; Trecator; Ethyonomide; Thioamide; Ethioniamide; Ethinamide; Ethylisothiamide; 2-Ethylpyridine-4-carbothioamide; 2-ethyl-4-thiocarbamoyl-4-pyridine; MFCD00057361; Trecator-SC; 2-Ethylthioisonicotinamide |
| Molecular Formula | C8H10N2S |
| Molecular Weight | 166.24 |
| Purity | ≥98.0 |
| Density | 1.17 g/cm3 |
| Boiling Point | 167 °C / 1mmHg |
| Melting Point | 164 °C |
| Appearance | powder |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Application | Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic. |
| EINECS | 208-628-9 |
| HTC | 2933990090 |
| PubChem ID | 24894350 |
| MDL Number | MFCD00057361 |
| SMILES | CCc1cc(ccn1)C(N)=S |
| InChI | 1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11) |
| InChI Key | AEOCXXJPGCBFJA-UHFFFAOYSA-N |
| NACRES Code | NA.26 |
| UNSPSC | 12352111 |
| Hazard Symbols | Transport |
| MSDS | msds/10397_1_536_33_4.pdf |
| Bioactivity | Ethionamide(2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.Target: AntibacterialEthionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. Ethionamide is a prodrug. It is activated by the enzyme EthA, a mono-oxygenase in Mycobacterium tuberculosis, and binds NAD+ to form an adduct which inhibits InhA in the same way as isoniazid. Expression of the ethA gene is controlled by EthR, a transcriptional repressor. It is understood that improving ethA expression will increase the efficacy of ethionamide and so EthR inhibitors are of great interest to co-drug developers. The action may be through disruption of mycolic acid [1, 2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Vannelli, T.A., A. Dykman, and P.R. Ortiz de Montellano, The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem, 2002. 277(15): p. 12824-9. [2]. Quemard, A., G. Laneelle, and C. Lacave, Mycolic acid synthesis: a target for ethionamide in mycobacteria? Antimicrob Agents Chemother, 1992. 36(6): p. 1316-21. Chemical & Physical Properties Density 1.17 g/cm3 Boiling Point 167 °C / 1mmHg Melting Point 164 °C Molecular Formula C8H10N2S Molecular Weight 166.24300 Flash Point 133.2ºC Exact Mass 166.05600 PSA 71.00000 LogP 1.97850 Index of Refraction 1.599 InChIKey AEOCXXJPGCBFJA-UHFFFAOYSA-N SMILES CCc1cc(C(N)=S)ccn1 Storage condition 2-8°C |
| Use of | Ethionamide(2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.Target: AntibacterialEthionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. Ethionamide is a prodrug. It is activated by the enzyme EthA, a mono-oxygenase in Mycobacterium tuberculosis, and binds NAD+ to form an adduct which inhibits InhA in the same way as isoniazid. Expression of the ethA gene is controlled by EthR, a transcriptional repressor. It is understood that improving ethA expression will increase the efficacy of ethionamide and so EthR inhibitors are of great interest to co-drug developers. The action may be through disruption of mycolic acid [1, 2]. Properties Articles50 Name ethionamide Synonym More Synonyms Ethionamide Biological Activity Description Ethionamide(2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.Target: AntibacterialEthionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. Ethionamide is a prodrug. It is activated by the enzyme EthA, a mono-oxygenase in Mycobacterium tuberculosis, and binds NAD+ to form an adduct which inhibits InhA in the same way as isoniazid. Expression of the ethA gene is controlled by EthR, a transcriptional repressor. It is understood that improving ethA expression will increase the efficacy of ethionamide and so EthR inhibitors are of great interest to co-drug developers. The action may be through disruption of mycolic acid [1, 2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Vannelli, T.A., A. Dykman, and P.R. Ortiz de Montellano, The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem, 2002. 277(15): p. 12824-9. [2]. Quemard, A., G. Laneelle, and C. Lacave, Mycolic acid synthesis: a target for ethionamide in mycobacteria? Antimicrob Agents Chemother, 1992. 36(6): p. 1316-21. Chemical & Physical Properties Molecular Formula C8H10N2S Exact Mass 166.05600 PSA 71.00000 LogP 1.97850 Index of Refraction 1.599 InChIKey AEOCXXJPGCBFJA-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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