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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 1-((1S,2S)-1-HYDROXY-1-(4-HYDROXYPHENYL)PROPAN-2-YL)-4-PHENYLPIPERIDIN-4-OL
1-((1S,2S)-1-HYDROXY-1-(4-HYDROXYPHENYL)PROPAN-2-YL)-4-PHENYLPIPERIDIN-4-OL structure, CAS 134234-12-1

1-((1S,2S)-1-HYDROXY-1-(4-HYDROXYPHENYL)PROPAN-2-YL)-4-PHENYLPIPERIDIN-4-OL

CAS Number134234-12-1

Synonyms1-[(1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)-2-propanyl]-4-phenyl-4-piperidinol; 1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol; 1-[(1S,2S)-2-Hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-4-phenyl-piperidin-4-ol; traxoprodil; CP 101606; (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol

Molecular FormulaC20H25NO3

Molecular Weight327.42

Purity≥98 (HPLC)%

Density1.2±0.1 g/cm3

Boiling Point534.4±50.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS0

MSDSChineseEnglish

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Cat. No.: 2A-1103682 Purity: ≥98 (HPLC)%
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Quality Control of [ 134234-12-1 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number134234-12-1
Catalog No.2A-1103682
Chinese Name曲索罗地
Synonyms1-[(1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)-2-propanyl]-4-phenyl-4-piperidinol; 1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol; 1-[(1S,2S)-2-Hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-4-phenyl-piperidin-4-ol; traxoprodil; CP 101606; (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol
Molecular FormulaC20H25NO3
Molecular Weight327.42
Purity≥98 (HPLC)
Density1.2±0.1 g/cm3
Boiling Point534.4±50.0 °C at 760 mmHg
Appearancepowder
Storage Condition2-8℃
ApplicationTraxoprodil (CP101,606) is a potent and selective NMDA antagonist that protects hippocampal neurons with an IC50 of 10 nM.
EINECS0
HTC0
UN(IATA)0
PubChem ID329825120
MDL NumberMFCD00926469
SMILESC[C@@H]([C@@H](O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3
InChI1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
InChI KeyQEMSVZNTSXPFJA-HNAYVOBHSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbolstransportation
MSDSmsds/103682_1_134234_12_1.pdf
BioactivityTraxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Target IC50: 10 nM (Neuroprotection)[1] In Vivo Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice[1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals' locomotor activity[2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures[3]. Animal Admin Rats[3] The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.)[3]. Mice[2] The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured[2]. References [1]. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. [2]. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. [3]. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 534.4±50.0 °C at 760 mmHg Molecular Formula C20H25NO3 Molecular Weight 327.417 Flash Point 290.3±28.8 °C Exact Mass 327.183441 PSA 63.93000 LogP 1.75 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.626 InChIKey QEMSVZNTSXPFJA-HNAYVOBHSA-N SMILES CC(C(O)c1ccc(O)cc1)N1CCC(O)(c2ccccc2)CC1 Storage condition 2-8℃
Use ofTraxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM. Properties Name 1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol Synonym More Synonyms CP-101,606 Biological Activity Description Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease IC50: 10 nM (Neuroprotection)[1] References [1]. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. [2]. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. [3]. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9. Chemical & Physical Properties Molecular Formula C20H25NO3 Exact Mass 327.183441 PSA 63.93000 Index of Refraction 1.626 InChIKey QEMSVZNTSXPFJA-HNAYVOBHSA-N Storage condition 2-8℃
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: TOXIC SOLID, ORGANIC, N.O.S. ((1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4- phenylpiperidino)-1-propanol) IMDG: TOXIC SOLID, ORGANIC, N.O.S. ((1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4- phenylpiperidino)-1-propanol) International air transport hazard regulations: Toxic solid, organic, n.o.s. ((1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)- 1-propanol) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: No 14.6 Special reminder to users No data available
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