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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 1,2-BIS-(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID
1,2-BIS-(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID structure, CAS 85233-19-8

1,2-BIS-(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID

CAS Number85233-19-8

Synonyms2,2',2'',2'''-[ethane-1,2-diylbis(oxybenzene-2,1-diylnitrilo)]tetraacetic acid; N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine]; 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; MFCD00036255; Bapeta; 2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid; 1,2-bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic acid; 5F-Bapta; 2,2',2'',2'''-[1,2-Ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetic acid; 2,2',2'',2'''-[Ethane-1,2-diylbis(oxy-2,1-phenylenenitrilo)]tetraacetic acid; 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; BAPTA

Molecular FormulaC22H24N2O10

Molecular Weight476.43

Purity98%

Density1.5±0.1 g/cm3

Boiling Point766.6±60.0 °C at 760 mmHg

Melting Point177-179 °C

Flash Point

Appearancepowder

EINECS0

MSDSChineseEnglish

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Cat. No.: 2A-0102942 Purity: 98%
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Quality Control of [ 85233-19-8 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number85233-19-8
Catalog No.2A-0102942
Chinese Name1,2-双(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸
Synonyms2,2',2'',2'''-[ethane-1,2-diylbis(oxybenzene-2,1-diylnitrilo)]tetraacetic acid; N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine]; 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; MFCD00036255; Bapeta; 2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid; 1,2-bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic acid; 5F-Bapta; 2,2',2'',2'''-[1,2-Ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetic acid; 2,2',2'',2'''-[Ethane-1,2-diylbis(oxy-2,1-phenylenenitrilo)]tetraacetic acid; 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; BAPTA
Molecular FormulaC22H24N2O10
Molecular Weight476.43
Purity98
Density1.5±0.1 g/cm3
Boiling Point766.6±60.0 °C at 760 mmHg
Melting Point177-179 °C
Appearancepowder
Storage ConditionRefrigerated, airtight, dry place at 2-8°C
ApplicationBAPTA is a specific Ca2+ chelator that inhibits intracellular reactive oxygen species (ROS) levels.
EINECS0
HTC0
UN(IATA)0
PubChem ID57653856
MDL NumberMFCD00036255
SMILESOC(=O)CN(CC(O)=O)c1ccccc1OCCOc2ccccc2N(CC(O)=O)CC(O)=O
InChI1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)
InChI KeyFTEDXVNDVHYDQW-UHFFFAOYSA-N
Beilstein/REAXYS5192406
NACRES CodeNA.23
UNSPSC12352103
Hazard Symbolstransportation
MSDSmsds/102942_1_85233_19_8.pdf
BioactivityBAPTA is a specific chelator of Ca2+, suppresses intracellular reactive oxygen species (ROS) levels. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Biochemical Assay Reagents Target Ca2+ chelator[1] In Vitro Regarding ROS generation, a Ca2+ specific chelator, BAPTA, suppresses ROS generation of Sodium lauryl sulfate (SLS)-exposed HaCaT keratinocytes[1]. Depolarization does not increase the resting open probability of the mechanoelectrical transducer (MET) current of Tmc1Bth/Bth OHCs, whereas raising the intracellular concentration of the Ca2+ chelator BAPTA causes smaller increases in resting open probability in Bthmutant outer hair cells (OHCs) than in wild-type control cells. In the presence of 0.1 mM BAPTA, nonsaturating bundle displacements causes the MET current to adapt in both genotypes, exactly as seen when 1 mM EGTA is used in the intracellular solution. In the presence of 10 mM intracellular BAPTA, the time-dependent MET current decline is abolished and the resting Popen increased to near 50% of the maximal MET current in OHCs from both Tmc1+/+ and Tmc1Bth/Bth mice. The relation between the MET current and bundle displacement shows that increasing the intracellular BAPTA concentration from 0.1 to 10 mM significantly increased (p<0.0001) the resting Popen of the MET current in both Tmc1+/+ (0.1 mM, 8±1.6%, n=4; 10 mM, 39.6±2.7%, n=5) and Tmc1Bth/Bth (0.1 mM, 10.4±2.2%, n=3; 10 mM, 46.5±9.9%, n=6). No significant differences are seen between the two genotypes for both BAPTA concentrations. However, 3 and 5 mM BAPTA are less effective in shifting the MET current-bundle displacement curves in Tmc1Bth/Bth than in Tmc1+/+ OHCs. In Tmc1+/+, increasing the BAPTA concentration from 0.1 mM to either 3 or 5 mM produces a highly significant increase in Popen (post hoc test from one-way ANOVA, p<0.01 and p<0.001, respectively); in Tmc1Bth/Bth, the same comparison produced no or a much reduced increase in Popen (n.s. and p<0.05, respectively)[2]. References [1]. Mizutani T, et al. Sodium Lauryl Sulfate Stimulates the Generation of Reactive Oxygen Species through Interactions with Cell Membranes. J Oleo Sci. 2016 Dec 1;65(12):993-1001. [2]. Corns LF, et al. Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells. J Neurosci. 2016 Jan 13;36(2):336-49. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 766.6±60.0 °C at 760 mmHg Melting Point 177-179 °C Molecular Formula C22H24N2O10 Molecular Weight 476.433 Flash Point 417.4±32.9 °C Exact Mass 476.143097 PSA 174.14000 LogP 0.13 Vapour Pressure 0.0±2.7 mmHg at 25°C Index of Refraction 1.657 InChIKey FTEDXVNDVHYDQW-UHFFFAOYSA-N SMILES O=C(O)CN(CC(=O)O)c1ccccc1OCCOc1ccccc1N(CC(=O)O)CC(=O)O Storage condition 2-8°C
Use ofBAPTA is a specific chelator of Ca2+, suppresses intracellular reactive oxygen species (ROS) levels. Properties Articles116 Name bapta Synonym More Synonyms BAPTA Biological Activity Description BAPTA is a specific chelator of Ca2+, suppresses intracellular reactive oxygen species (ROS) levels. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Biochemical Assay Reagents Ca2+ chelator[1] References [1]. Mizutani T, et al. Sodium Lauryl Sulfate Stimulates the Generation of Reactive Oxygen Species through Interactions with Cell Membranes. J Oleo Sci. 2016 Dec 1;65(12):993-1001. [2]. Corns LF, et al. Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells. J Neurosci. 2016 Jan 13;36(2):336-49. Chemical & Physical Properties Molecular Formula C22H24N2O10 Exact Mass 476.143097 PSA 174.14000 Index of Refraction 1.657 InChIKey FTEDXVNDVHYDQW-UHFFFAOYSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip.
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