CAS Number68278-23-9
SynonymsOrnithine, 2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1); Eflornithine HCl Monohydrate; DFMO HCl; 2-(Difluoromethyl)ornithine hydrochloride hydrate; dfmo; 2-(Difluoromethyl)-DL-ornithine Monohydrochloride Monohydrate; MFCD00274036; EINECS 269-532-0; EflornithineHcl; Eflornithine (hydrochloride); 2-(Difluoromethyl)-DL-ornithine monohydrochloride; DFMO hydrochloride hydrate; Eflornithine hydrochloride hydrate; MDL 71782 A; Vaniqa
Molecular FormulaC6H13ClF2N2O2
Molecular Weight218.633
Purity98%
Boiling Point347ºC at 760 mmHg
Melting Point181-184°C
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68278-23-9 |
| Catalog No. | 2A-9010288 |
| Chinese Name | 盐酸依氟乌氨酸 |
| Synonyms | Ornithine, 2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1); Eflornithine HCl Monohydrate; DFMO HCl; 2-(Difluoromethyl)ornithine hydrochloride hydrate; dfmo; 2-(Difluoromethyl)-DL-ornithine Monohydrochloride Monohydrate; MFCD00274036; EINECS 269-532-0; EflornithineHcl; Eflornithine (hydrochloride); 2-(Difluoromethyl)-DL-ornithine monohydrochloride; DFMO hydrochloride hydrate; Eflornithine hydrochloride hydrate; MDL 71782 A; Vaniqa |
| Molecular Formula | C6H13ClF2N2O2 |
| Molecular Weight | 218.633 |
| Purity | 98 |
| Boiling Point | 347ºC at 760 mmHg |
| Melting Point | 181-184°C |
| Appearance | white solid |
| Water Solubility | H2O: >10 mg/mL, soluble |
| Application | Eflornithine hydrochloride is a specific and irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medicine used to treat African trypanosomiasis and excessive facial hair gr |
| HTC | 2922499990 |
| MDL Number | MFCD00274036 |
| SMILES | [H+].[Cl-].NCCCC(N)(C(F)F)C(O)=O |
| InChI | InChI=1S/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H |
| InChI Key | InChIKey=VKDGNNYJFSHYKD-UHFFFAOYSA-N |
| MSDS | msds/10288_1_68278_23_9.pdf |
| Use of | Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Properties Name 2,5-diamino-2-(difluoromethyl)pentanoic acid,hydrochloride Synonym More Synonyms DFMO Biological Activity Description Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others In Vivo Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. References [1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. Chemical & Physical Properties Exact Mass 236.073929 PSA 89.34000 LogP 1.97510 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride, hydrate CAS REGISTRY NUMBER : 68278-23-9 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 7-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,55A,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 10-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,55A,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 7-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 39,103,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 11-19 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,55A,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 11-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,55A,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 7-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 39,103,1989 Safety Information WGK Germany 3 HS Code 2922499990 |
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