CAS Number157716-52-4
SynonymsPiperidinium (4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl; Perifosine (KRX-0401); 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium Inner Salt; Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt; Perifosine; 1,1-Dimethylpiperidinium-4-yl-octadecylphosphat; 1,1-Dimethyl-4-piperidiniumyl octadecyl phosphate; 1,1-Dimethylpiperidinium-4-yl octadecyl phosphate; 1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate; (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
Molecular FormulaC25H52O4N1P1
Molecular Weight461.67
Purity96+%
Melting Point271-272° (dec)
Appearancewhite to beige
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 157716-52-4 |
| Catalog No. | 2A-0102676 |
| Chinese Name | Perifosine (KRX-0401) |
| Synonyms | Piperidinium (4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl; Perifosine (KRX-0401); 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium Inner Salt; Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt; Perifosine; 1,1-Dimethylpiperidinium-4-yl-octadecylphosphat; 1,1-Dimethyl-4-piperidiniumyl octadecyl phosphate; 1,1-Dimethylpiperidinium-4-yl octadecyl phosphate; 1,1-Dimethylpiperidin-1-ium-4-yl octadecyl phosphate; (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate |
| Molecular Formula | C25H52O4N1P1 |
| Molecular Weight | 461.67 |
| Purity | 96+ |
| Melting Point | 271-272° (dec) |
| Appearance | white to beige |
| Water Solubility | H2O: soluble10mg/mL, clear |
| Storage Condition | ?20°C |
| Application | Perifosine is an orally available Akt inhibitor. Perifosine has anti-proliferative activity against most cells, with an IC50 of 0.6-8.9 μM. |
| EINECS | 0 |
| HTC | 2933399090 |
| UN(IATA) | 0 |
| MDL Number | MFCD00927554 |
| SMILES | CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](C)(C)CC1 |
| InChI | InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3 |
| InChI Key | SZFPYBIJACMNJV-UHFFFAOYSA-N |
| MSDS | msds/102676_1_157716_52_4.pdf |
| Use of | Perifosine is an oral Akt inhibitor. All cells are sensitive to the antiproliferative properties of Perifosine with an IC50 of ~0.6-8.9 μM. Properties Name perifosine Synonym More Synonyms Perifosine (KRX-0401) Biological Activity Description Perifosine is an oral Akt inhibitor. All cells are sensitive to the antiproliferative properties of Perifosine with an IC50 of ~0.6-8.9 μM. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer References [1]. Momota H, et al. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res, 2005, 65(16), 7429-7435. [2]. Vyomesh Patel, et al. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res, 2002, 62(5), 14 [3]. Chen L, et al. Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures. Epilepsia. 2012 Nov;53(11):2026-33. Chemical & Physical Properties Molecular Formula C25H52NO4P Exact Mass 461.363403 PSA 68.40000 Appearance of Characters white to beige InChIKey SZFPYBIJACMNJV-UHFFFAOYSA-N Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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