CAS Number109971-63-3
Synonymscombretastatin A1 Z; Combretastatin A-1; 3-methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol; (Z)-3',4,4',5'-Tetramethoxystilbene-2,3-diol; (Z)-3,4,4',5-Tetramethoxy-2',3'-dihydroxystilbene; Combretastatin A1( 3-Methoxy-6-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-benzene-1,2-diol ); (Z)-3-Methoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol; (Z)-1-[3',4',5'-trimethoxyphenyl]-2-[2'',3''-dihydroxy-4''-methoxyphenyl]ethene; 3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]-1,2-benzenediol; combretastatin A-2; 3-Methoxy-6-[(Z)-3,4,5-trimethoxystyryl]-1,2-benzenediol; 3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]benzene-1,2-diol
Molecular FormulaC18H20O6
Molecular Weight332.35
Purity96+%
Density1.3±0.1 g/cm3
Boiling Point528.4±50.0 °C at 760 mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 109971-63-3 |
| Catalog No. | 2A-0102468 |
| Chinese Name | 康普瑞汀A-1 |
| Synonyms | combretastatin A1 Z; Combretastatin A-1; 3-methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol; (Z)-3',4,4',5'-Tetramethoxystilbene-2,3-diol; (Z)-3,4,4',5-Tetramethoxy-2',3'-dihydroxystilbene; Combretastatin A1( 3-Methoxy-6-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-benzene-1,2-diol ); (Z)-3-Methoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol; (Z)-1-[3',4',5'-trimethoxyphenyl]-2-[2'',3''-dihydroxy-4''-methoxyphenyl]ethene; 3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]-1,2-benzenediol; combretastatin A-2; 3-Methoxy-6-[(Z)-3,4,5-trimethoxystyryl]-1,2-benzenediol; 3-Methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]benzene-1,2-diol |
| Molecular Formula | C18H20O6 |
| Molecular Weight | 332.35 |
| Purity | 96+ |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 528.4±50.0 °C at 760 mmHg |
| Storage Condition | 2-8°C, protected from light, dry and sealed |
| Application | Combrestatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine binding site of tubulin. Combrestatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization-me |
| EINECS | 0 |
| HTC | 2909499000 |
| UN(IATA) | 0 |
| MDL Number | C18H20O6 |
| SMILES | COc1ccc(C=Cc2cc(OC)c(OC)c(OC)c2)c(O)c1O |
| InChI | InChI=1S/C18H20O6/c1-21-13-8-7-12(16(19)17(13)20)6-5-11-9-14(22-2)18(24-4)15(10-11)23-3/h5-10,19-20H,1-4H3/b6-5+ |
| InChI Key | YUSYSJSHVJULID-WAYWQWQTSA-N |
| MSDS | msds/102468_1_109971_63_3.pdf |
| Use of | Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects[1][2][3]. Properties Name combretastatin a1 Synonym More Synonyms Combretastatin A-1 Biological Activity Description Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Microtubule/Tubulin[1] References [2]. Mao J, et, al. Combretastatin A-1 phosphate, a microtubule inhibitor, acts on both hepatocellular carcinoma cells and tumor-associated macrophages by inhibiting the Wnt/β-catenin pathway. Cancer Lett. 2016 Sep 28;380(1):134-43. Chemical & Physical Properties Molecular Formula C18H20O6 Exact Mass 332.125977 PSA 77.38000 Index of Refraction 1.627 InChIKey YUSYSJSHVJULID-WAYWQWQTSA-N Safety Information Hazard Codes Xi HS Code 2909499000 Synthetic Route 444992-83-0 Combretastatin ... 109971-63-3 Literature: Tetrahedron Letters, , vol. 47, # 7 p. 1101 - 1103 (Z)-1-[3',4... 109971-68-8 Combretastatin ... 109971-63-3 Literature: Journal of Natural Products, , vol. 72, # 3 p. 414 - 421 (Z)-1-[3',4... 1400573-38-7 Combretastatin ... 109971-63-3 Literature: Journal of Natural Products, , vol. 72, # 3 p. 414 - 421 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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