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Dofetilide structure, CAS 115256-11-6

Dofetilide

CAS Number115256-11-6

SynonymsN-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfon Amide; Dofetilidum; Xelide; N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide; MFCD00869707; Dofetilide; 1-MSPMPE; b-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide; N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide; Dofetilida; Tikosyn

Molecular FormulaC19H27N3O5S2

Molecular Weight441.56

Purity98%

Density1.3±0.1 g/cm3

Boiling Point614.1±65.0 °C at 760 mmHg

Melting Point147-1490C

Flash Point

AppearanceOff-white or light yellow crystalline powder

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9010220 Purity: 98%
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Quality Control of [ 115256-11-6 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number115256-11-6
Catalog No.2A-9010220
Chinese Name多非利特
SynonymsN-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfon Amide; Dofetilidum; Xelide; N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide; MFCD00869707; Dofetilide; 1-MSPMPE; b-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide; N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide; Dofetilida; Tikosyn
Molecular FormulaC19H27N3O5S2
Molecular Weight441.56
Purity98
Density1.3±0.1 g/cm3
Boiling Point614.1±65.0 °C at 760 mmHg
Melting Point147-1490C
AppearanceOff-white or light yellow crystalline powder
Storage ConditionStore at RT
ApplicationDofetilide (Tikosyn) is a type III antiarrhythmic drug that blocks potassium channels.
PubChem ID329749665
MDL NumberMFCD00869707
SMILESCN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2
InChI1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
InChI KeyIXTMWRCNAAVVAI-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/10220_1_115256_11_6.pdf
BioactivityDofetilide(Tikosyn) is a class III antiarrhythmic agent.Target: Potassium ChannelIn patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality [1]. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Maisch, B., et al., [Pregnancy and cardiomyopathies]. Herz, 2003. 28(3): p. 196-208. [2]. Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 614.1±65.0 °C at 760 mmHg Melting Point 147-1490C Molecular Formula C19H27N3O5S2 Molecular Weight 441.565 Flash Point 325.2±34.3 °C Exact Mass 441.139221 PSA 121.57000 LogP 1.56 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.614 InChIKey IXTMWRCNAAVVAI-UHFFFAOYSA-N SMILES CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 Storage condition Store at RT
Use ofDofetilide(Tikosyn) is a class III antiarrhythmic agent.Target: Potassium ChannelIn patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality [1]. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations [2]. Properties Articles52 Name dofetilide Synonym More Synonyms Dofetilide Biological Activity Description Dofetilide(Tikosyn) is a class III antiarrhythmic agent.Target: Potassium ChannelIn patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality [1]. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Maisch, B., et al., [Pregnancy and cardiomyopathies]. Herz, 2003. 28(3): p. 196-208. [2]. Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55. Chemical & Physical Properties Molecular Formula C19H27N3O5S2 Exact Mass 441.139221 PSA 121.57000 Index of Refraction 1.614 InChIKey IXTMWRCNAAVVAI-UHFFFAOYSA-N Storage condition Store at RT
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a guarantee as to the properties of this product. The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip.
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