| Chemical & Physical Properties | |
|---|---|
| CAS Number | 16689-14-8 |
| Catalog No. | 2A-0102015 |
| Chinese Name | H-Leu-Leu-OMe·HCl |
| Synonyms | methyl 2-[(2-amino-4-methylpentanoyl)amino]-4-methylpentanoate,hydrobromide; LLME,HBr Leu-Leu-Ome,HBr |
| Molecular Formula | C13H27BrN2O3 |
| Molecular Weight | 339.27 |
| Purity | ≥97 (TLC) |
| Appearance | powder |
| Storage Condition | -20°C, sealed, dry |
| Application | L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide is a dipeptide condensation product of L-leucine methyl ester produced by human monocytes or polymorphonuclear leukocytes and can selectively elimi |
| EINECS | 0 |
| HTC | 2924199090 |
| UN(IATA) | 0 |
| PubChem ID | 24896476 |
| MDL Number | MFCD00216855 |
| SMILES | Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C |
| InChI | 1S/C13H26N2O3.BrH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5;/h8-11H,6-7,14H2,1-5H3,(H,15,16);1H |
| InChI Key | QIPBCIHWFATZOF-UHFFFAOYSA-N |
| NACRES Code | NA.26 |
| UNSPSC | 12352209 |
| Hazard Symbols | transportation |
| MSDS | msds/102015_1_16689_14_8.pdf |
| Bioactivity | L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress[1][2][3]. Related Catalog Research Areas >> Inflammation/Immunology In Vitro L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[3]. L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[2]. References [1]. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48. [2]. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7. [3]. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423. Chemical & Physical Properties Molecular Formula C13H27BrN2O3 Molecular Weight 339.26900 Exact Mass 338.12100 PSA 81.42000 LogP 3.11300 InChIKey QIPBCIHWFATZOF-ACMTZBLWSA-N SMILES Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C |
| Use of | L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress[1][2][3]. Properties Name Leu-Leu methyl ester hydrobromide Synonym More Synonyms Biological Activity Description L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress[1][2][3]. Related Catalog Research Areas >> Inflammation/Immunology References [1]. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48. [2]. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7. [3]. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423. Chemical & Physical Properties Molecular Formula C13H27BrN2O3 Exact Mass 338.12100 PSA 81.42000 LogP 3.11300 InChIKey QIPBCIHWFATZOF-ACMTZBLWSA-N SMILES Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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