CAS Number512-04-9
SynonymsEINECS 208-134-3; 3β-Hydroxy-5-spirostene; Diosgenin; (25R)-5-Spirosten-3β-ol; MFCD00016887; DELTA 5,20A,22A,25D-SPIROSTEN-3BETA-OL
Molecular FormulaC27H42O3
Molecular Weight414.62
Purity≥93%
Density1.1±0.1 g/cm3
Boiling Point527.1±50.0 °C at 760 mmHg
Melting Point205-208°C
Appearancepowder
EINECS208-134-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 512-04-9 |
| Catalog No. | 2A-9010188 |
| Chinese Name | 薯蓣皂苷元 |
| Synonyms | EINECS 208-134-3; 3β-Hydroxy-5-spirostene; Diosgenin; (25R)-5-Spirosten-3β-ol; MFCD00016887; DELTA 5,20A,22A,25D-SPIROSTEN-3BETA-OL |
| Molecular Formula | C27H42O3 |
| Molecular Weight | 414.62 |
| Purity | ≥93 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 527.1±50.0 °C at 760 mmHg |
| Melting Point | 205-208°C |
| Appearance | powder |
| Water Solubility | chloroform: 20 mg/mL, clear, slightly yellow |
| Storage Condition | Brown glass bottle with light-sealed packaging. St |
| Application | Diosgenin, a steroidal saponin, inhibits the STAT3 signaling pathway. |
| EINECS | 208-134-3 |
| HTC | 2932999099 |
| UN(IATA) | NA |
| PubChem ID | 24893501 |
| MDL Number | MFCD00016887 |
| SMILES | [H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2 |
| InChI | 1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 |
| InChI Key | WQLVFSAGQJTQCK-VKROHFNGSA-N |
| Beilstein/REAXYS | 94582 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10188_1_512_04_9.pdf |
| Bioactivity | Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway. Related Catalog Research Areas >> Metabolic Disease Natural Products >> Steroids Target STAT3 In Vitro In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[1]. Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibition occurring at around 100 μM[2]. In Vivo Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice[3]. References [1]. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin asmultifunctional compounds against Alzheimer's disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324-7331 [2]. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207. [3]. Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):286-96. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 527.1±50.0 °C at 760 mmHg Melting Point 205-208°C Molecular Formula C27H42O3 Molecular Weight 414.621 Flash Point 272.6±30.1 °C Exact Mass 414.313385 PSA 38.69000 LogP 5.84 Vapour Pressure 0.0±3.1 mmHg at 25°C Index of Refraction 1.564 InChIKey WQLVFSAGQJTQCK-VKROHFNGSA-N SMILES CC1CCC2(OC1)OC1CC3C4CC=C5CC(O)CCC5(C)C4CCC3(C)C1C2C Storage condition Refrigerator Water Solubility chloroform: 20 mg/mL, clear, slightly yellow |
| Use of | Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway. Properties Articles59 Name diosgenin Synonym More Synonyms Diosgenin Biological Activity Description Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway. Related Catalog Research Areas >> Metabolic Disease Natural Products >> Steroids In Vivo Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice[3]. References [1]. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin asmultifunctional compounds against Alzheimer's disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324-7331 [2]. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207. [3]. Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):286-96. Chemical & Physical Properties Molecular Formula C27H42O3 Exact Mass 414.313385 PSA 38.69000 Index of Refraction 1.564 InChIKey WQLVFSAGQJTQCK-VKROHFNGSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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