![(S)-6-((4-CHLOROPHENYL)(1H-1,2,4-TRIAZOL-1-YL)METHYL)-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOLE structure, CAS 129731-10-8](/structures/120000/101813_1_129731_10_8.png)
CAS Number129731-10-8
SynonymsVorozolum; 6-[(S)-(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole; (S)-6-[(4-Chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-1H-benzotriazole; Vorozolum [INN-Latin]; (+)-(S)-6-(p-Chloro-α-1H-1,2,4-triazol-1-ylbenzyl)-1-methyl-1H-benzotriazole; Rivizor; (+)-(S)-6-[4-Chloro-a-(1H-1,2,4-triazol-1-yl)benzyl]-1-methyl-1H-benzotriazole; Vorozole; Rivizor (TN); Vorozol [INN-Spanish]; Vorozol
Molecular FormulaC16H13ClN6
Molecular Weight324.77
Purity96+%
Density1.44g/cm3
Boiling Point575.1ºC at 760 mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 129731-10-8 |
| Catalog No. | 2A-1101813 |
| Chinese Name | 伏氯唑 |
| Synonyms | Vorozolum; 6-[(S)-(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole; (S)-6-[(4-Chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-1H-benzotriazole; Vorozolum [INN-Latin]; (+)-(S)-6-(p-Chloro-α-1H-1,2,4-triazol-1-ylbenzyl)-1-methyl-1H-benzotriazole; Rivizor; (+)-(S)-6-[4-Chloro-a-(1H-1,2,4-triazol-1-yl)benzyl]-1-methyl-1H-benzotriazole; Vorozole; Rivizor (TN); Vorozol [INN-Spanish]; Vorozol |
| Molecular Formula | C16H13ClN6 |
| Molecular Weight | 324.77 |
| Purity | 96+ |
| Density | 1.44g/cm3 |
| Boiling Point | 575.1ºC at 760 mmHg |
| Application | Vorozole is a highly effective, selective, orally active non-steroidal aromatase inhibitor [1][2]. Vorozole has antitumor activity in vivo. Vorozole has potential application prospects in breast cance |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 12014601 |
| MDL Number | C16H13ClN6 |
| SMILES | Cn1nnc2ccc(C(c3ccc(Cl)cc3)n3cncn3)cc21 |
| InChI | InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3 |
| InChI Key | XLMPPFTZALNBFS-INIZCTEOSA-N |
| MSDS | msds/101813_1_129731_10_8.pdf |
| Use of | Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3]. Properties Name 6-[(S)-(4-chlorophenyl)-(1,2,4-triazol-1-yl)methyl]-1-methylbenzotriazole Synonym More Synonyms Vorozole Biological Activity Description Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Aromatase In Vitro Vorozole inhibits aromatase activity with an IC50s of 1.4 nM in FSH-stimulated rat granulosa cells[4]. References [1]. Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):617-21. [2]. Wiseman LR, et al. Vorozole. Drugs Aging. 1997 Sep;11(3):245-50; discussion 251-2. [3]. Lubet RA,et al. Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model. Carcinogenesis. 1998 Aug;19(8):1345-51. [4]. Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):617-21. Chemical & Physical Properties Exact Mass 324.08900 PSA 61.42000 LogP 2.85090 Index of Refraction 1.738 InChIKey XLMPPFTZALNBFS-INIZCTEOSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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