CAS Number1194044-20-6
Synonyms(4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; LY2811376
Molecular FormulaC15H14N4S1F2
Molecular Weight320.37
Purity96+%
Density1.4±0.1 g/cm3
Boiling Point486.5±55.0 °C at 760 mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1194044-20-6 |
| Catalog No. | 2A-0101646 |
| Chinese Name | (4S)-4-[2,4-二氟-5-(5-嘧啶)苯基]-5,6-二氢-4-甲基-4H-1,3-噻嗪-2-胺 |
| Synonyms | (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; LY2811376 |
| Molecular Formula | C15H14N4S1F2 |
| Molecular Weight | 320.37 |
| Purity | 96+ |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 486.5±55.0 °C at 760 mmHg |
| Storage Condition | Room temperature, dry, sealed |
| Application | LY2811376 is an orally available, non-peptide β-secretase (BACE1) inhibitor with an IC50 value of 239 nM-249 nM. It can reduce the secretion of Aβ protein with an EC50 value of 300 nM. |
| EINECS | 0 |
| HTC | 2934999090 |
| UN(IATA) | 0 |
| MDL Number | MFCD18074525 |
| SMILES | CC1(c2cc(-c3cncnc3)c(F)cc2F)CCSC(N)=N1 |
| InChI Key | MJQMRGWYPNIERM-HNNXBMFYSA-N |
| MSDS | msds/101646_1_1194044_20_6.pdf |
| Use of | LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Properties Name (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Synonym More Synonyms LY2811376 Biological Activity Description LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Related Catalog Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease IC50: 239-249 nM (BACE1) References [1]. May PC, et al. Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. J Neurosci. 2011 Nov 16;31(46):16507-16516. [2]. Zhang X, et al. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9734-9. [3]. Ghosh AK, et al. Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer's Disease. ChemMedChem. 2015 Sep;10(9):1463-6. [4]. Filser S, et al. Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions. Biol Psychiatry. 2015 Apr 15;77(8):729-39. Chemical & Physical Properties Molecular Formula C15H14F2N4S Exact Mass 320.090729 PSA 89.46000 Index of Refraction 1.662 InChIKey MJQMRGWYPNIERM-HNNXBMFYSA-N Safety Information Hazard Codes Xi HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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