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Dihydrocytochalasin B structure, CAS 39156-67-7

Dihydrocytochalasin B

CAS Number39156-67-7

Synonyms2,3-Dihydro-cytochalasin B; 21,22-dihydro-phomin; EINECS 254-324-4; 21,22-Dihydrocytochalalsin B; CYTOCHALASIN B,DIHYDRO; 21,22-dihydro-cytochalasin-B; dihydrocytocholasin-B; 7(S),20(R)-dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione; DHCB; (7S,13E,16R,20R)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione; MFCD00010541

Molecular FormulaC29H39NO5

Molecular Weight481.62

Purity98.00%

Density1.194g/cm3

Boiling Point727.474ºC at 760 mmHg

Melting Point203-205ºC

Flash Point

Appearancepowder

EINECS254-324-4

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-9010152 Purity: 98.00%
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Quality Control of [ 39156-67-7 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number39156-67-7
Catalog No.2A-9010152
Chinese Name二氢细胞松弛素B
Synonyms2,3-Dihydro-cytochalasin B; 21,22-dihydro-phomin; EINECS 254-324-4; 21,22-Dihydrocytochalalsin B; CYTOCHALASIN B,DIHYDRO; 21,22-dihydro-cytochalasin-B; dihydrocytocholasin-B; 7(S),20(R)-dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione; DHCB; (7S,13E,16R,20R)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione; MFCD00010541
Molecular FormulaC29H39NO5
Molecular Weight481.62
Purity98.00
Density1.194g/cm3
Boiling Point727.474ºC at 760 mmHg
Melting Point203-205ºC
Appearancepowder
Storage ConditionSealed, stored at -18ºC
ApplicationDihydrocytochalasin B is a cytokinesis inhibitor that changes cell morphology, similar to cytochalasin B; it does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts actin structure a
EINECS254-324-4
PubChem ID24893505
MDL NumberMFCD12910542
SMILESC[C@@H]1CCC[C@@H](O)CCC(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI1S/C29H39NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14,18-19,22-24,26-27,31,33H,3,7,9-10,13,15-17H2,1-2H3,(H,30,34)/b14-8+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI KeyWIULKAASLBZREV-RXPQEOCGSA-N
NACRES CodeNA.32
UNSPSC12352202
Hazard Symbols6.1(a)
MSDSmsds/10152_1_39156_67_7.pdf
BioactivityDihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis, causes cell rounding and a loss of actin microfilament bundles[2]. Dihydrocytochalasin B is related to transcytoplasmic movement of calcium by inhibiting active calcium transport and causes a Ca+increase in the mucosal scrapings[3]. Related Catalog Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex Research Areas >> Others References [1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70. [2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51. [3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62. Chemical & Physical Properties Density 1.194g/cm3 Boiling Point 727.474ºC at 760 mmHg Melting Point 203-205ºC Molecular Formula C29H39NO5 Molecular Weight 481.62400 Flash Point 393.762ºC Exact Mass 481.28300 PSA 95.86000 LogP 4.04490 Index of Refraction 1.584 InChIKey WIULKAASLBZREV-CJKMDAKDSA-N SMILES C=C1C(C)C2C(Cc3ccccc3)NC(=O)C23OC(=O)CCC(O)CCCC(C)CC=CC3C1O Storage condition -20℃
Use ofProperties Articles26 Name dihydrocytochalasin b Synonym More Synonyms Dihydrocytochalasin B Biological Activity Related Catalog Research Areas >> Others References [2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51. Chemical & Physical Properties Molecular Formula C29H39NO5 Exact Mass 481.28300 PSA 95.86000 LogP 4.04490 Index of Refraction 1.584 InChIKey WIULKAASLBZREV-CJKMDAKDSA-N Storage condition -20℃
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24- oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24- oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione) International air transport hazard regulations: Toxic solid, organic, n.o.s. (7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24- oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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