CAS Number186452-09-5
SynonymsL-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester; GPI; (S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; 3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)-L-prolinate; gpi-1046
Molecular FormulaC20H28O4N2
Molecular Weight360.45
Purity96+%
Density1.1±0.1 g/cm3
Boiling Point501.5±60.0 °C at 760 mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 186452-09-5 |
| Catalog No. | 2A-0101502 |
| Chinese Name | 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯 |
| Synonyms | L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester; GPI; (S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate; 3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)-L-prolinate; gpi-1046 |
| Molecular Formula | C20H28O4N2 |
| Molecular Weight | 360.45 |
| Purity | 96+ |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 501.5±60.0 °C at 760 mmHg |
| Storage Condition | -20°C, sealed, dry |
| Application | GPI-1046 is an immunophilin ligand without antibiotic effect that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the PFC and NAc core. GPI-1046 is an analog of FK506 that exh |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD00953146 |
| SMILES | CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCc1cccnc1 |
| InChI Key | OQAHHWOPVDDWHD-INIZCTEOSA-N |
| MSDS | msds/101502_1_186452_09_5.pdf |
| Use of | GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2]. Properties Name 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate Synonym More Synonyms GPI-1046 Biological Activity Description GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35. [2]. Eberling JL, et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol. 2002 Dec;178(2):236-42. Chemical & Physical Properties Molecular Formula C20H28N2O4 Exact Mass 360.204895 PSA 90.40000 Index of Refraction 1.529 InChIKey OQAHHWOPVDDWHD-INIZCTEOSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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