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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > (S)-2-(4,6-DIMETHYLPYRIMIDIN-2-YLOXY)-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
(S)-2-(4,6-DIMETHYLPYRIMIDIN-2-YLOXY)-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID structure, CAS 177036-94-1

(S)-2-(4,6-DIMETHYLPYRIMIDIN-2-YLOXY)-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID

CAS Number177036-94-1

SynonymsLetairis; (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid; (S)-2-(4,6-Dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid; ambrisentan; (2S)-2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid; UNII-HW6NV07QEC

Molecular FormulaC22H22N2O4

Molecular Weight378.42

Purity≥98 (HPLC)%

Density1.228g/cm3

Boiling Point551.1ºC at 760mmHg

Melting Point>150°C (dec.)

Flash Point

Appearancepowder

EINECS0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-2101096 Purity: ≥98 (HPLC)%
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Quality Control of [ 177036-94-1 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number177036-94-1
Catalog No.2A-2101096
Chinese Name安倍生坦
SynonymsLetairis; (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid; (S)-2-(4,6-Dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid; ambrisentan; (2S)-2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid; UNII-HW6NV07QEC
Molecular FormulaC22H22N2O4
Molecular Weight378.42
Purity≥98 (HPLC)
Density1.228g/cm3
Boiling Point551.1ºC at 760mmHg
Melting Point>150°C (dec.)
Appearancepowder
Storage Condition-20°C Freezer
ApplicationAmbrisentan is a selective ET type A receptor (ETAR) antagonist.
EINECS0
HTC2933599090
UN(IATA)0
MDL NumberMFCD08672619
SMILESCC1=CC(C)=NC(O[C@@H](C(C2=CC=CC=C2)(OC)C3=CC=CC=C3)C(O)=O)=N1
InChI1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
InChI KeyOUJTZYPIHDYQMC-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC41121706
MSDSmsds/101096_1_177036_94_1.pdf
Use ofAmbrisentan is a selective ET type A receptor (ETAR) antagonist. Properties Name (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid Synonym More Synonyms Ambrisentan Biological Activity Description Ambrisentan is a selective ET type A receptor (ETAR) antagonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Cardiovascular Disease ETA receptor[1] In Vitro Ambrisentan is an endothelin type A receptor antagonist[1]. Ambrisentan induces Nrf2 activation. Endothelial permeability increased in BMEC monolayers at 24 h of hypoxia exposure and compared to vehicle control, Ambrisentan attenuates hypoxia-induced BMEC leak. These results are reversed when prior to treatment BMEC are transfected with siRNA against Nrf2[2]. References [1]. Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8(22):933-41. [2]. Lisk C, et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73. Chemical & Physical Properties Molecular Formula C22H22N2O4 Exact Mass 378.15800 PSA 81.54000 LogP 3.51560 Index of Refraction 1.593 InChIKey OUJTZYPIHDYQMC-LJQANCHMSA-N Safety Information RTECS UA2459660 HS Code 2933599090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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