| Chemical & Physical Properties | |
|---|---|
| CAS Number | 83435-67-0 |
| Catalog No. | 2A-9010035 |
| Chinese Name | 盐酸地拉普利 |
| Synonyms | MFCD00884619; delapril hcl |
| Molecular Formula | C26H33ClN2O5 |
| Molecular Weight | 489.01 |
| Purity | 98 |
| Boiling Point | 659.7ºC at 760 mmHg |
| Melting Point | 169ºC |
| Appearance | White crystalline powder |
| Storage Condition | Room Temperature |
| Application | Delapril is an angiotensin-converting enzyme (ACE) inhibitor used to treat cardiovascular disease. |
| MDL Number | C26H33ClN2O5 |
| SMILES | CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N(CC(=O)O)C1Cc2ccccc2C1.Cl |
| InChI | InChI=1S/C26H32N2O5.ClH/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22;/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30);1H/t18-,23-;/m0./s1 |
| InChI Key | FDJCVHVKXFIEPJ-JCNFZFLDSA-N |
| MSDS | msds/10035_1_83435_67_0.pdf |
| Bioactivity | Delapril is an angiotensin-converting enzyme (ACE) inhibitor for the treatment of cardiovascular diseases[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Target ACE[1] In Vivo Delapril (3 mg/kg; administered orally for 2 weeks) exerts potent ACE inhibitory activity in spontaneously hypertensive rat (SHR) [1]. Delapril (1-10 mg/kg; orally) exerts a marked and long-lasting antihypertensive action in various experimental models of hypertension[1]. Animal Model: SHR[1] Dosage: 3 mg/kg Administration: Administered orally; 2 weeks Result: Exerted potent ACE inhibitory activity. Animal Model: 2-kidney, 1-clip hypertensive Rats, Dogs, and SHR[1] Dosage: 1-10 mg/kg Administration: Oral Result: Exerted a marked and long-lasting antihypertensive action. References [1]. Razzetti R, et al. Pharmacokinetic and pharmacologic properties of delapril, a lipophilic nonsulfhydryl angiotensin-converting enzyme inhibitor. Am J Cardiol. 1995 Jun 16;75(18):7F-12F. Chemical & Physical Properties Boiling Point 659.7ºC at 760 mmHg Melting Point 169ºC Molecular Formula C26H33ClN2O5 Molecular Weight 489.004 Flash Point 352.7ºC Exact Mass 488.207794 PSA 95.94000 LogP 3.80250 InChIKey FDJCVHVKXFIEPJ-JCNFZFLDSA-N SMILES CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N(CC(=O)O)C1Cc2ccccc2C1.Cl |
| Use of | Delapril is an angiotensin-converting enzyme (ACE) inhibitor for the treatment of cardiovascular diseases[1]. Properties Name Delapril Hydrochloride Synonym More Synonyms delapril hcl Biological Activity Description Delapril is an angiotensin-converting enzyme (ACE) inhibitor for the treatment of cardiovascular diseases[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) References [1]. Razzetti R, et al. Pharmacokinetic and pharmacologic properties of delapril, a lipophilic nonsulfhydryl angiotensin-converting enzyme inhibitor. Am J Cardiol. 1995 Jun 16;75(18):7F-12F. Chemical & Physical Properties Exact Mass 488.207794 PSA 95.94000 LogP 3.80250 InChIKey FDJCVHVKXFIEPJ-JCNFZFLDSA-N |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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